Epithalon Peptide Helps Human Cells Overcome the Hayflick Division Limit
The tetrapeptide Epithalon (AEDG) enabled human pulmonary fibroblasts to exceed the Hayflick limit of cell divisions, extending replicative lifespan through telomerase activation — demonstrating anti-aging at the cellular replication level.
Quick Facts
What This Study Found
Epithalon peptide treatment enabled human somatic cells to overcome the Hayflick division limit (normally ~50 divisions), extending replicative lifespan through telomerase activation and telomere maintenance.
Key Numbers
How They Did This
in-vitro study examining anti-aging and peptide-design.
Why This Research Matters
Advances understanding of anti-aging, peptide-design, immune-function.
The Bigger Picture
Contributes to peptide research with clinical implications.
What This Study Doesn't Tell Us
Study-specific limitations; see abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation potential to evaluate.
Trust & Context
- Key Stat:
- Key finding Epithalon peptide treatment enabled human somatic cells to overcome the Hayflick division limit (normally ~50 divisions), extending replicative lifesp
- Evidence Grade:
- preliminary evidence from in-vitro study.
- Study Age:
- Published in 2004.
- Original Title:
- Peptide promotes overcoming of the division limit in human somatic cell.
- Published In:
- Bulletin of experimental biology and medicine, 137(5), 503-6 (2004)
- Authors:
- Khavinson, V Kh(3), Bondarev, I E(2), Butyugov, A A(2), Smirnova, T D
- Database ID:
- RPEP-00933
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Epithalon Peptide Helps Human Cells Overcome the Hayflick Division Limit
What was found?
The tetrapeptide Epithalon (AEDG) enabled human pulmonary fibroblasts to exceed the Hayflick limit of cell divisions, extending replicative lifespan through telomerase activation — demonstrating anti-aging at the cellular replication level.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-00933APA
Khavinson, V Kh; Bondarev, I E; Butyugov, A A; Smirnova, T D. (2004). Peptide promotes overcoming of the division limit in human somatic cell.. Bulletin of experimental biology and medicine, 137(5), 503-6.
MLA
Khavinson, V Kh, et al. "Peptide promotes overcoming of the division limit in human somatic cell.." Bulletin of experimental biology and medicine, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Peptide promotes overcoming of the division limit in human s..." RPEP-00933. Retrieved from https://rethinkpeptides.com/research/khavinson-2004-peptide-promotes-overcoming-of
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.