Temporal changes in natriuretic peptides, norepinephrine, and aldosterone after MI predicted ventricular remodeling and prognosis in the Val-HeFT substudy — the trajectory matters more than a single measurement.
Key findingSerial changes in BNP, ANP, norepinephrine, and aldosterone after MI in the Val-HeFT RCT substudy predicted ventricular remodeling and clinical outcom
What the researchers found
Serial changes in BNP, ANP, norepinephrine, and aldosterone after MI in the Val-HeFT RCT substudy predicted ventricular remodeling and clinical outcomes — neurohormonal trajectory (pattern over time) provided prognostic information beyond single baseline measurements.
Why it matters
Relevant for natriuretic-peptides, cardiovascular.
How the study worked
RCT study on natriuretic-peptides, cardiovascular.
What this study cannot tell us
See abstract.
How to read the evidence
strong evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide/biomarker research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Usefulness of temporal changes in neurohormones as markers of ventricular remodeling and prognosis in patients with left ventricular systolic dysfunction and heart failure receiving either candesartan or enalapril or both.
The American journal of cardiology, 96(5), 698-704
Citation
Yan, Raymond T; White, Michel; Yan, Andrew T; Yusuf, Salim; Rouleau, Jean L; Maggioni, Aldo P; Hall, Christian; Latini, Roberto; Afzal, Rizwan; Floras, John; Masson, Serge; McKelvie, Robert S. (2005). Usefulness of temporal changes in neurohormones as markers of ventricular remodeling and prognosis in patients with left ventricular systolic dysfunction and heart failure receiving either candesartan or enalapril or both.. The American journal of cardiology, 96(5), 698-704.