Amino-terminal pro-C-type natriuretic peptide (NT-proCNP) was elevated in heart failure and correlated with disease severity, adding an endothelial-derived biomarker to complement cardiac-derived BNP/ANP.
Key findingNT-proCNP (endothelial origin, unlike cardiac ANP/BNP) was elevated in heart failure and correlated with severity, providing a biomarker reflecting va
What the researchers found
NT-proCNP (endothelial origin, unlike cardiac ANP/BNP) was elevated in heart failure and correlated with severity, providing a biomarker reflecting vascular endothelial dysfunction to complement cardiac-derived natriuretic peptides.
Why it matters
Relevant for natriuretic-peptides, cardiovascular, clinical-trials.
How the study worked
cohort study on natriuretic-peptides, cardiovascular.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2004.
The bigger picture
Advances peptide/biomarker research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Amino-terminal pro-C-type natriuretic peptide in heart failure.
Hypertension (Dallas, Tex. : 1979), 43(1), 94-100
Citation
Wright, Sue P; Prickett, Tim C R; Doughty, Robert N; Frampton, Chris; Gamble, Greg D; Yandle, Tim G; Sharpe, Norman; Richards, Mark. (2004). Amino-terminal pro-C-type natriuretic peptide in heart failure.. Hypertension (Dallas, Tex. : 1979), 43(1), 94-100.