Stapled Peptide Helix Activates Cancer Cell Death In Vivo: A Breakthrough in Peptide Drug Design
A hydrocarbon-stapled BH3 helix peptide activated the apoptotic pathway in live mice, achieving tumor reduction — demonstrating that stapled peptides can work as cancer drugs in vivo for the first time.
Quick Facts
What This Study Found
A hydrocarbon-stapled BH3 alpha-helix peptide activated apoptosis in vivo in a mouse leukemia model, producing tumor reduction — the first demonstration that stapled peptide technology achieves in-vivo anticancer efficacy through intracellular target engagement.
Key Numbers
How They Did This
animal-study study on cyclic-peptides, cancer.
Why This Research Matters
Relevant for cyclic-peptides, cancer, peptide-design.
The Bigger Picture
Advances peptide therapeutics/biomarker research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding A hydrocarbon-stapled BH3 alpha-helix peptide activated apoptosis in vivo in a mouse leukemia model, producing tumor reduction — the first demonstrati
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2004.
- Original Title:
- Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
- Published In:
- Science (New York, N.Y.), 305(5689), 1466-70 (2004)
- Authors:
- Walensky, Loren D(4), Kung, Andrew L, Escher, Iris, Malia, Thomas J, Barbuto, Scott, Wright, Renee D, Wagner, Gerhard, Verdine, Gregory L, Korsmeyer, Stanley J
- Database ID:
- RPEP-00992
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Stapled Peptide Helix Activates Cancer Cell Death In Vivo: A Breakthrough in Peptide Drug Design
What was found?
A hydrocarbon-stapled BH3 helix peptide activated the apoptotic pathway in live mice, achieving tumor reduction — demonstrating that stapled peptides can work as cancer drugs in vivo for the first time.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-00992APA
Walensky, Loren D; Kung, Andrew L; Escher, Iris; Malia, Thomas J; Barbuto, Scott; Wright, Renee D; Wagner, Gerhard; Verdine, Gregory L; Korsmeyer, Stanley J. (2004). Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.. Science (New York, N.Y.), 305(5689), 1466-70.
MLA
Walensky, Loren D, et al. "Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.." Science (New York, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Activation of apoptosis in vivo by a hydrocarbon-stapled BH3..." RPEP-00992. Retrieved from https://rethinkpeptides.com/research/walensky-2004-activation-of-apoptosis-in
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.