Crystal Structure of Anti-Cancer Macrocyclic Peptide Bound to Its Target Reveals Drug Design Details
Crystal structures of a high-affinity macrocyclic peptide bound to the Grb2 SH2 cancer signaling domain revealed precise binding interactions, guiding further optimization of this anticancer peptide drug approach.
Quick Facts
What This Study Found
X-ray crystal structures of a high-affinity macrocyclic peptide mimetic bound to Grb2 SH2 domain revealed specific hydrogen bonds and hydrophobic contacts driving picomolar binding — providing the structural blueprint for optimizing this cancer drug scaffold.
Key Numbers
How They Did This
in-vitro study on cyclic-peptides, cancer.
Why This Research Matters
Relevant for cyclic-peptides, cancer, peptide-design.
The Bigger Picture
Advances peptide research with clinical implications.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding X-ray crystal structures of a high-affinity macrocyclic peptide mimetic bound to Grb2 SH2 domain revealed specific hydrogen bonds and hydrophobic cont
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2005.
- Original Title:
- Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain.
- Published In:
- Journal of molecular biology, 353(1), 104-15 (2005)
- Authors:
- Phan, Jason, Shi, Zhen-Dan, Burke, Terrence R(2), Waugh, David S
- Database ID:
- RPEP-01074
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Crystal Structure of Anti-Cancer Macrocyclic Peptide Bound to Its Target Reveals Drug Design Details
What was found?
Crystal structures of a high-affinity macrocyclic peptide bound to the Grb2 SH2 cancer signaling domain revealed precise binding interactions, guiding further optimization of this anticancer peptide drug approach.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-01074APA
Phan, Jason; Shi, Zhen-Dan; Burke, Terrence R; Waugh, David S. (2005). Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain.. Journal of molecular biology, 353(1), 104-15.
MLA
Phan, Jason, et al. "Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain.." Journal of molecular biology, 2005.
RethinkPeptides
RethinkPeptides Research Database. "Crystal structures of a high-affinity macrocyclic peptide mi..." RPEP-01074. Retrieved from https://rethinkpeptides.com/research/phan-2005-crystal-structures-of-a
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.