Ultrastructural imaging showed antimicrobial peptides from lactoferrin disrupted Candida and E. coli membranes through distinct morphological patterns — pore formation in bacteria and complete membrane destruction in yeast.
Key findingTransmission electron microscopy revealed lactoferrin-derived peptides disrupted C. albicans membranes through complete bilayer destruction and E. col
What the researchers found
Transmission electron microscopy revealed lactoferrin-derived peptides disrupted C. albicans membranes through complete bilayer destruction and E. coli through pore-like lesions — visually distinct killing mechanisms for yeast versus bacteria.
Why it matters
Relevant for antimicrobial-peptides, infection.
How the study worked
in-vitro study on antimicrobial-peptides, infection.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide/biomarker research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Ultrastructural effects of antimicrobial peptides from bovine lactoferrin on the membranes of Candida albicans and Escherichia coli.
Peptides, 26(9), 1537-42
Citation
van der Kraan, Marieke I A; van Marle, Jan; Nazmi, Kamran; Groenink, Jasper; van 't Hof, Wim; Veerman, Enno C I; Bolscher, Jan G M; Nieuw Amerongen, Arie V. (2005). Ultrastructural effects of antimicrobial peptides from bovine lactoferrin on the membranes of Candida albicans and Escherichia coli.. Peptides, 26(9), 1537-42.