Bovine lactoferricin B inhibited DNA, RNA, and protein synthesis in both E. coli and Bacillus subtilis at sub-bactericidal concentrations, revealing intracellular macromolecular synthesis inhibition as a killing mechanism beyond membrane disruption.
Key findingLactoferricin B inhibited DNA, RNA, and protein synthesis in E. coli and B. subtilis at sub-MIC concentrations, demonstrating an intracellular mechani
What the researchers found
Lactoferricin B inhibited DNA, RNA, and protein synthesis in E. coli and B. subtilis at sub-MIC concentrations, demonstrating an intracellular mechanism of antimicrobial action complementing its known membrane-disrupting activity.
Why it matters
Relevant for antimicrobial-peptides, infection.
How the study worked
in-vitro study on antimicrobial-peptides, infection.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2004.
The bigger picture
Advances peptide therapeutics/biomarker research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Lactoferricin B inhibits bacterial macromolecular synthesis in Escherichia coli and Bacillus subtilis.
FEMS microbiology letters, 237(2), 377-84
Citation
Ulvatne, Hilde; Samuelsen, Ørjan; Haukland, Hanne H; Krämer, Manuela; Vorland, Lars H. (2004). Lactoferricin B inhibits bacterial macromolecular synthesis in Escherichia coli and Bacillus subtilis.. FEMS microbiology letters, 237(2), 377-84.