A Lab Test That Predicts Which Peptide Drugs Will Cause Injection Site Reactions
A cell-based MRGPRX2 assay reliably identified peptide compounds causing injection site histamine release and edema in ex vivo skin samples, serving as a replacement for postmortem animal evaluation.
John, Linu M; Dalsgaard, Charlotte M; Jeppesen, Claus B; Conde-Frieboes, Kilian W; Baumann, Katrine; Knudsen, Niels P H; Skov, Per S; Wulff, Birgitte S · Drug Development/Validation Study