Using GHS-R knockout mice, researchers proved definitively that ghrelin's GH-releasing AND appetite-stimulating effects both require the growth hormone secretagogue receptor — settling the receptor debate.
Key findingGHS-R knockout mice showed no GH release or appetite stimulation from ghrelin administration, definitively proving both effects require the GHS-R — se
What the researchers found
GHS-R knockout mice showed no GH release or appetite stimulation from ghrelin administration, definitively proving both effects require the GHS-R — settling the debate about whether ghrelin uses alternative receptors for appetite.
Why it matters
Relevant for ghrp, hormone-optimization, weight-loss, receptor-signaling.
How the study worked
animal-study study on ghrp, hormone-optimization.
What this study cannot tell us
See abstract.
How to read the evidence
strong evidence.
When this study was published
Published in 2004.
The bigger picture
Advances peptide therapeutics/biomarker research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor.
Proceedings of the National Academy of Sciences of the United States of America, 101(13), 4679-84
Citation
Sun, Yuxiang; Wang, Pei; Zheng, Hui; Smith, Roy G. (2004). Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor.. Proceedings of the National Academy of Sciences of the United States of America, 101(13), 4679-84.