Proof That Ghrelin's GH Release and Appetite Effects Both Require the GHS Receptor
Using GHS-R knockout mice, researchers proved definitively that ghrelin's GH-releasing AND appetite-stimulating effects both require the growth hormone secretagogue receptor — settling the receptor debate.
Quick Facts
What This Study Found
GHS-R knockout mice showed no GH release or appetite stimulation from ghrelin administration, definitively proving both effects require the GHS-R — settling the debate about whether ghrelin uses alternative receptors for appetite.
Key Numbers
How They Did This
animal-study study on ghrp, hormone-optimization.
Why This Research Matters
Relevant for ghrp, hormone-optimization, weight-loss, receptor-signaling.
The Bigger Picture
Advances peptide therapeutics/biomarker research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding GHS-R knockout mice showed no GH release or appetite stimulation from ghrelin administration, definitively proving both effects require the GHS-R — se
- Evidence Grade:
- strong evidence.
- Study Age:
- Published in 2004.
- Original Title:
- Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor.
- Published In:
- Proceedings of the National Academy of Sciences of the United States of America, 101(13), 4679-84 (2004)
- Authors:
- Sun, Yuxiang(3), Wang, Pei, Zheng, Hui, Smith, Roy G
- Database ID:
- RPEP-00982
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Proof That Ghrelin's GH Release and Appetite Effects Both Require the GHS Receptor
What was found?
Using GHS-R knockout mice, researchers proved definitively that ghrelin's GH-releasing AND appetite-stimulating effects both require the growth hormone secretagogue receptor — settling the receptor debate.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-00982APA
Sun, Yuxiang; Wang, Pei; Zheng, Hui; Smith, Roy G. (2004). Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor.. Proceedings of the National Academy of Sciences of the United States of America, 101(13), 4679-84.
MLA
Sun, Yuxiang, et al. "Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor.." Proceedings of the National Academy of Sciences of the United States of America, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Ghrelin stimulation of growth hormone release and appetite i..." RPEP-00982. Retrieved from https://rethinkpeptides.com/research/sun-2004-ghrelin-stimulation-of-growth
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.