A Ghrelin Receptor Antagonist That Blocks GH But Paradoxically Increases Appetite
A novel GHS-R1a antagonist blocked ghrelin-induced GH secretion but paradoxically stimulated appetite, revealing complex receptor pharmacology where blocking the receptor for one function doesn't block all functions.
Quick Facts
What This Study Found
A novel GHS-R1a antagonist blocked ghrelin-induced GH release but paradoxically increased food intake, suggesting inverse agonism or biased antagonism at the constitutively active receptor — complex pharmacology where blocking one ghrelin function doesn't block another.
Key Numbers
How They Did This
animal-study study on ghrp, weight-loss.
Why This Research Matters
Relevant for ghrp, weight-loss, hormone-optimization, receptor-signaling.
The Bigger Picture
Advances peptide research with clinical implications.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding A novel GHS-R1a antagonist blocked ghrelin-induced GH release but paradoxically increased food intake, suggesting inverse agonism or biased antagonism
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2005.
- Original Title:
- A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain.
- Published In:
- Neuroendocrinology, 81(5), 339-49 (2005)
- Authors:
- Halem, Heather A(3), Taylor, John E(4), Dong, Jesse Z(3), Shen, Yeelana, Datta, Rakesh, Abizaid, Alfonso, Diano, Sabrina, Horvath, Tamas L, Culler, Michael D
- Database ID:
- RPEP-01043
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
A Ghrelin Receptor Antagonist That Blocks GH But Paradoxically Increases Appetite
What was found?
A novel GHS-R1a antagonist blocked ghrelin-induced GH secretion but paradoxically stimulated appetite, revealing complex receptor pharmacology where blocking the receptor for one function doesn't block all functions.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01043APA
Halem, Heather A; Taylor, John E; Dong, Jesse Z; Shen, Yeelana; Datta, Rakesh; Abizaid, Alfonso; Diano, Sabrina; Horvath, Tamas L; Culler, Michael D. (2005). A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain.. Neuroendocrinology, 81(5), 339-49.
MLA
Halem, Heather A, et al. "A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain.." Neuroendocrinology, 2005.
RethinkPeptides
RethinkPeptides Research Database. "A novel growth hormone secretagogue-1a receptor antagonist t..." RPEP-01043. Retrieved from https://rethinkpeptides.com/research/halem-2005-a-novel-growth-hormone
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.