Both N-terminal proANP and NT-proBNP predicted cardiovascular events in stable community heart disease patients, with combination measurement providing the most comprehensive risk assessment.
Key findingN-ANP and NT-proBNP both independently predicted cardiovascular events in stable community heart disease patients, with combined measurement providing
What the researchers found
N-ANP and NT-proBNP both independently predicted cardiovascular events in stable community heart disease patients, with combined measurement providing superior risk stratification for identifying those who would develop CHF or cardiac death.
Why it matters
Relevant for natriuretic-peptides, cardiovascular, clinical-trials.
How the study worked
cohort study on natriuretic-peptides, cardiovascular.
What this study cannot tell us
See abstract.
How to read the evidence
strong evidence.
When this study was published
Published in 2004.
The bigger picture
Advances peptide therapeutics/biomarker research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
N-terminal pro-atrial natriuretic peptide (N-ANP) and N-terminal pro-B-type natriuretic peptide (N-BNP) in the prediction of death and heart failure in unselected patients following acute myocardial infarction.
Clinical science (London, England : 1979), 107(3), 309-16
Citation
Squire, Iain B; O'Brien, Russell J; Demme, Bettina; Davies, Joan E; Ng, Leong L. (2004). N-terminal pro-atrial natriuretic peptide (N-ANP) and N-terminal pro-B-type natriuretic peptide (N-BNP) in the prediction of death and heart failure in unselected patients following acute myocardial infarction.. Clinical science (London, England : 1979), 107(3), 309-16.