Collagen-binding peptide reverses bone loss in a mouse model of cerebral palsy based on clinical databases.
Quick Facts
What This Study Found
Collagen-binding peptide increased trabecular thickness, collagen content, and osteoblast differentiation markers (RUNX2, osteocalcin) in a CP mouse model developed from clinical transcriptome analysis of 119 CP patients.
Key Numbers
119 CP patients; SPP1 downregulated; 140 mice; CBP increased trabecular thickness, collagen, bone turnover; RUNX2 and osteocalcin upregulated vs saline
How They Did This
Translational study: transcriptome analysis of 119 CP patients and 13 healthy controls, development of a hypoxic-ischemic brain injury CP mouse model (140 mice), and testing of collagen-binding peptide vs saline control.
Why This Research Matters
Bone loss in cerebral palsy causes fractures and pain but has no approved drug treatment. A peptide that directly stimulates bone building could fill this critical gap.
What This Study Doesn't Tell Us
Mouse model may not fully replicate human CP bone loss. The collagen-binding peptide was tested only short-term. No comparison to existing osteoporosis drugs. Human clinical trials are needed.
Trust & Context
- Original Title:
- Collagen-binding peptide reverses bone loss in a mouse model of cerebral palsy based on clinical databases.
- Published In:
- Annals of physical and rehabilitation medicine, 64(3), 101445 (2021)
- Database ID:
- RPEP-05758
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-05758APA
Shin, Yoon-Kyum; Heo, Jeong Hyun; Lee, Jue Yeon; Park, Yoon-Jeong; Cho, Sung-Rae. (2021). Collagen-binding peptide reverses bone loss in a mouse model of cerebral palsy based on clinical databases.. Annals of physical and rehabilitation medicine, 64(3), 101445. https://doi.org/10.1016/j.rehab.2020.09.009
MLA
Shin, Yoon-Kyum, et al. "Collagen-binding peptide reverses bone loss in a mouse model of cerebral palsy based on clinical databases.." Annals of physical and rehabilitation medicine, 2021. https://doi.org/10.1016/j.rehab.2020.09.009
RethinkPeptides
RethinkPeptides Research Database. "Collagen-binding peptide reverses bone loss in a mouse model..." RPEP-05758. Retrieved from https://rethinkpeptides.com/research/shin-2021-collagenbinding-peptide-reverses-bone
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.