The BNP/ANP ratio was more useful than either peptide alone for determining the severity of mitral regurgitation, with the ratio reflecting the hemodynamic burden of valve leakage on the ventricle.
Key findingThe BNP/ANP ratio correlated better with mitral regurgitation severity than either peptide alone, with the ratio reflecting the disproportionate ventr
What the researchers found
The BNP/ANP ratio correlated better with mitral regurgitation severity than either peptide alone, with the ratio reflecting the disproportionate ventricular stress from volume overload — a refined biomarker approach for valvular heart disease assessment.
Why it matters
Relevant for natriuretic-peptides, cardiovascular.
How the study worked
cross-sectional study.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Usefulness of the brain natriuretic peptide to atrial natriuretic peptide ratio in determining the severity of mitral regurgitation.
The Canadian journal of cardiology, 23(4), 295-300
Citation
Shimamoto, Ken; Kusumoto, Miyako; Sakai, Rieko; Watanabe, Hirota; Ihara, Syunichi; Koike, Natsuka; Kawana, Masatoshi. (2007). Usefulness of the brain natriuretic peptide to atrial natriuretic peptide ratio in determining the severity of mitral regurgitation.. The Canadian journal of cardiology, 23(4), 295-300.