Staphylococcus aureus small colony variants (SCVs) showed natural resistance to lactoferricin B, associated with their altered cell membrane and reduced growth rate — identifying a bacterial subtype that evades this antimicrobial peptide.
Key findingS. aureus small colony variants were naturally resistant to lactoferricin B, with resistance associated with altered cell membrane composition and met
What the researchers found
S. aureus small colony variants were naturally resistant to lactoferricin B, with resistance associated with altered cell membrane composition and metabolic state — identifying a clinically important bacterial subtype (found in chronic infections) that evades antimicrobial peptide killing.
Why it matters
Relevant for antimicrobial-peptides, infection.
How the study worked
in-vitro study on antimicrobial-peptides, infection.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide/biomarker research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Staphylococcus aureus small colony variants are resistant to the antimicrobial peptide lactoferricin B.
The Journal of antimicrobial chemotherapy, 56(6), 1126-9
Citation
Samuelsen, Orjan; Haukland, Hanne Husom; Kahl, Barbara C; von Eiff, Christof; Proctor, Richard A; Ulvatne, Hilde; Sandvik, Kjersti; Vorland, Lars H. (2005). Staphylococcus aureus small colony variants are resistant to the antimicrobial peptide lactoferricin B.. The Journal of antimicrobial chemotherapy, 56(6), 1126-9.