Serial passage of S. aureus with sub-inhibitory lactoferricin B induced resistance through membrane modifications, but resistant bacteria showed reduced fitness — resistance is possible but comes at a biological cost.
Key findingS. aureus developed lactoferricin B resistance through serial passage with sub-MIC concentrations, involving membrane composition changes, but resista
What the researchers found
S. aureus developed lactoferricin B resistance through serial passage with sub-MIC concentrations, involving membrane composition changes, but resistant strains showed reduced growth fitness — antimicrobial peptide resistance is achievable but costly for bacteria.
Why it matters
Relevant for antimicrobial-peptides, infection.
How the study worked
in-vitro study on antimicrobial-peptides, infection.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide/biomarker research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus.
FEBS letters, 579(16), 3421-6
Citation
Samuelsen, Orjan; Haukland, Hanne H; Jenssen, Håvard; Krämer, Manuela; Sandvik, Kjersti; Ulvatne, Hilde; Vorland, Lars H. (2005). Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus.. FEBS letters, 579(16), 3421-6.