Histone Arginine Methylation Regulates Neuropeptide Y Expression in the Basolateral Amygdala to Promote Reward-Seeking Behaviour.
Quick Facts
What This Study Found
Histone arginine methylation by PRMT4 in the basolateral amygdala controls neuropeptide Y expression and is required for reward-seeking behavior in rats.
Key Numbers
Increased PRMT4 and NPY in BLA after operant conditioning; H3R17me2a enrichment at NPY promoter; PRMT4 siRNA/inhibitor reduced nose-poke activity; NPY peptide restored activity
How They Did This
Rat operant conditioning for sucrose pellets. PRMT4 and NPY measured by immunohistochemistry. Chromatin immunoprecipitation for histone marks at NPY promoter. Intra-BLA injection of PRMT4 siRNA, inhibitor, and NPY peptide.
Why This Research Matters
Understanding how brain chemistry drives reward-seeking could inform treatments for overeating and addiction, where neuropeptide Y plays a key role.
What This Study Doesn't Tell Us
Rat model; brain reward circuits differ from humans. Sucrose reward may not generalize to other reward types. Invasive brain injections are not clinically translatable. Small group sizes typical of behavioral neuroscience.
Trust & Context
- Original Title:
- Histone Arginine Methylation Regulates Neuropeptide Y Expression in the Basolateral Amygdala to Promote Reward-Seeking Behaviour.
- Published In:
- Cellular and molecular neurobiology, 45(1), 92 (2025)
- Database ID:
- RPEP-13363
Evidence Hierarchy
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-13363APA
Sagarkar, Sneha; Rotti, Deepa; Raykar, Sahil; Upadhye, Gauri A; Sakharkar, Amul J. (2025). Histone Arginine Methylation Regulates Neuropeptide Y Expression in the Basolateral Amygdala to Promote Reward-Seeking Behaviour.. Cellular and molecular neurobiology, 45(1), 92. https://doi.org/10.1007/s10571-025-01614-5
MLA
Sagarkar, Sneha, et al. "Histone Arginine Methylation Regulates Neuropeptide Y Expression in the Basolateral Amygdala to Promote Reward-Seeking Behaviour.." Cellular and molecular neurobiology, 2025. https://doi.org/10.1007/s10571-025-01614-5
RethinkPeptides
RethinkPeptides Research Database. "Histone Arginine Methylation Regulates Neuropeptide Y Expres..." RPEP-13363. Retrieved from https://rethinkpeptides.com/research/sagarkar-2025-histone-arginine-methylation-regulates
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Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.