Bremelanotide Rescues Men Who Fail Viagra: A Brain Approach When Blood Flow Drugs Don't Work
Bremelanotide (PT-141) significantly improved erectile function in men who had failed sildenafil treatment, in a double-blind placebo-controlled RCT — demonstrating the brain-acting melanocortin approach works where peripheral drugs fail.
Quick Facts
What This Study Found
SC bremelanotide significantly improved erectile responses in sildenafil-failure ED patients in a double-blind, placebo-controlled RCT — demonstrating melanocortin central mechanism (desire/arousal) rescues patients where PDE5 peripheral mechanism (blood flow) fails.
Key Numbers
How They Did This
RCT study.
Why This Research Matters
Relevant for pt-141, sexual-health.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding SC bremelanotide significantly improved erectile responses in sildenafil-failure ED patients in a double-blind, placebo-controlled RCT — demonstrating
- Evidence Grade:
- strong evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo controlled study.
- Published In:
- The Journal of urology, 179(3), 1066-71 (2008)
- Database ID:
- RPEP-01413
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Bremelanotide Rescues Men Who Fail Viagra: A Brain Approach When Blood Flow Drugs Don't Work
What was found?
Bremelanotide (PT-141) significantly improved erectile function in men who had failed sildenafil treatment, in a double-blind placebo-controlled RCT — demonstrating the brain-acting melanocortin approach works where peripheral drugs fail.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01413APA
Safarinejad, Mohammad Reza; Hosseini, Seyyed Yousof. (2008). Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo controlled study.. The Journal of urology, 179(3), 1066-71. https://doi.org/10.1016/j.juro.2007.10.063
MLA
Safarinejad, Mohammad Reza, et al. "Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo controlled study.." The Journal of urology, 2008. https://doi.org/10.1016/j.juro.2007.10.063
RethinkPeptides
RethinkPeptides Research Database. "Salvage of sildenafil failures with bremelanotide: a randomi..." RPEP-01413. Retrieved from https://rethinkpeptides.com/research/safarinejad-2008-salvage-of-sildenafil-failures
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.