PT-141 selectively facilitated sexual solicitation behavior in female rats without affecting other behaviors, confirming melanocortin receptors specifically modulate female sexual desire — supporting development for women's sexual dysfunction.
Key findingPT-141 (melanocortin agonist) selectively increased sexual solicitation (proceptive) behavior in female rats without affecting locomotion or other beh
What the researchers found
PT-141 (melanocortin agonist) selectively increased sexual solicitation (proceptive) behavior in female rats without affecting locomotion or other behaviors — demonstrating specific melanocortin modulation of female sexual desire/motivation.
Why it matters
Relevant for pt-141, sexual-health, receptor-signaling, clinical-trials.
How the study worked
animal-study study on pt-141, sexual-health.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2004.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist.
Proceedings of the National Academy of Sciences of the United States of America, 101(27), 10201-4
Citation
Pfaus, James G; Shadiack, Annette; Van Soest, Tanya; Tse, Maric; Molinoff, Perry. (2004). Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist.. Proceedings of the National Academy of Sciences of the United States of America, 101(27), 10201-4.