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Natriuretic Peptides 2008: Updated Biology, Therapeutic Uses, and Cardiovascular Disease Implications

ReviewModerate evidence
The takeaway

Updated comprehensive review of natriuretic peptide biology (ANP, BNP, CNP, DNP, urodilatin), therapeutic applications (nesiritide, sacubitril concept), and cardiovascular disease biomarker/therapy roles.

Key finding

Updated natriuretic peptide review covering expanded family (ANP, BNP, CNP, DNP, urodilatin), therapeutic developments (nesiritide, neprilysin inhibit

What the researchers found

Updated natriuretic peptide review covering expanded family (ANP, BNP, CNP, DNP, urodilatin), therapeutic developments (nesiritide, neprilysin inhibition concept), and comprehensive cardiovascular biomarker and therapeutic applications — the 2008 state of the art.

Why it matters

Relevant for natriuretic-peptides, cardiovascular.

How the study worked

review study.

What this study cannot tell us

See abstract.

How to read the evidence

moderate evidence.

When this study was published

Published in 2008.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.
  • Clinical translation to evaluate.

Common questions

What was studied?
Natriuretic Peptides 2008: Updated Biology, Therapeutic Uses, and Cardiovascular Disease Implications
What was found?
Updated comprehensive review of natriuretic peptide biology (ANP, BNP, CNP, DNP, urodilatin), therapeutic applications (nesiritide, sacubitril concept), and cardiovascular disease biomarker/therapy roles.

Read the original research

Natriuretic peptides: an update on bioactivity, potential therapeutic use, and implication in cardiovascular diseases.

American journal of hypertension, 21(7), 733-41

Citation

Rubattu, Speranza; Sciarretta, Sebastiano; Valenti, Valentina; Stanzione, Rosita; Volpe, Massimo. (2008). Natriuretic peptides: an update on bioactivity, potential therapeutic use, and implication in cardiovascular diseases.. American journal of hypertension, 21(7), 733-41. https://doi.org/10.1038/ajh.2008.174