How CRF Binds Its Receptor: The Molecular Recognition of the Stress Peptide
Structural and mutagenesis studies revealed how CRF is recognized by its GPCR receptor CRFR1 through a two-step binding model, identifying specific residues critical for both binding and receptor activation.
Quick Facts
What This Study Found
CRF-CRFR1 molecular recognition involves a two-step binding model: C-terminal CRF helix binds the receptor N-terminus (affinity), then N-terminal CRF contacts the receptor core (activation) — structural basis for designing CRF receptor-selective drugs.
Key Numbers
How They Did This
in-vitro study.
Why This Research Matters
Relevant for neuropeptides, receptor-signaling, anxiety-mood.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding CRF-CRFR1 molecular recognition involves a two-step binding model: C-terminal CRF helix binds the receptor N-terminus (affinity), then N-terminal CRF
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1.
- Published In:
- The Journal of biological chemistry, 283(47), 32900-12 (2008)
- Authors:
- Pioszak, Augen A(2), Parker, Naomi R, Suino-Powell, Kelly, Xu, H Eric
- Database ID:
- RPEP-01403
Evidence Hierarchy
Frequently Asked Questions
What was studied?
How CRF Binds Its Receptor: The Molecular Recognition of the Stress Peptide
What was found?
Structural and mutagenesis studies revealed how CRF is recognized by its GPCR receptor CRFR1 through a two-step binding model, identifying specific residues critical for both binding and receptor activation.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01403APA
Pioszak, Augen A; Parker, Naomi R; Suino-Powell, Kelly; Xu, H Eric. (2008). Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1.. The Journal of biological chemistry, 283(47), 32900-12. https://doi.org/10.1074/jbc.M805749200
MLA
Pioszak, Augen A, et al. "Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1.." The Journal of biological chemistry, 2008. https://doi.org/10.1074/jbc.M805749200
RethinkPeptides
RethinkPeptides Research Database. "Molecular recognition of corticotropin-releasing factor by i..." RPEP-01403. Retrieved from https://rethinkpeptides.com/research/pioszak-2008-molecular-recognition-of-corticotropinreleasing
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.