CRF Peptide Family in Inflammation: Beyond Stress to Peripheral Immune Regulation
CRF and urocortin peptides have direct peripheral anti-inflammatory and pro-inflammatory effects through CRF receptors on immune and tissue cells, with therapeutic potential for inflammatory bowel disease, arthritis, and skin inflammation.
Quick Facts
What This Study Found
CRF family peptides (CRF, urocortin 1-3) modulate peripheral inflammation through CRF1 (generally pro-inflammatory) and CRF2 (generally anti-inflammatory) receptors on immune cells, gut, and skin — with therapeutic applications for IBD, arthritis, and dermatitis.
Key Numbers
How They Did This
review study on neuropeptides, inflammation.
Why This Research Matters
Relevant for neuropeptides, inflammation, anxiety-mood, receptor-signaling.
The Bigger Picture
Advances peptide research with clinical implications.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding CRF family peptides (CRF, urocortin 1-3) modulate peripheral inflammation through CRF1 (generally pro-inflammatory) and CRF2 (generally anti-inflammat
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2005.
- Original Title:
- The corticotropin-releasing factor (CRF) family of neuropeptides in inflammation: potential therapeutic applications.
- Published In:
- Current medicinal chemistry, 12(13), 1503-12 (2005)
- Authors:
- Gravanis, Achille(2), Margioris, Andrew N
- Database ID:
- RPEP-01039
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was studied?
CRF Peptide Family in Inflammation: Beyond Stress to Peripheral Immune Regulation
What was found?
CRF and urocortin peptides have direct peripheral anti-inflammatory and pro-inflammatory effects through CRF receptors on immune and tissue cells, with therapeutic potential for inflammatory bowel disease, arthritis, and skin inflammation.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01039APA
Gravanis, Achille; Margioris, Andrew N. (2005). The corticotropin-releasing factor (CRF) family of neuropeptides in inflammation: potential therapeutic applications.. Current medicinal chemistry, 12(13), 1503-12.
MLA
Gravanis, Achille, et al. "The corticotropin-releasing factor (CRF) family of neuropeptides in inflammation: potential therapeutic applications.." Current medicinal chemistry, 2005.
RethinkPeptides
RethinkPeptides Research Database. "The corticotropin-releasing factor (CRF) family of neuropept..." RPEP-01039. Retrieved from https://rethinkpeptides.com/research/gravanis-2005-the-corticotropinreleasing-factor-crf
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.