Browse more peptide research, methods and limitations.
Brainstem GLP-1 neurons modulate physiological satiation (not nausea/malaise) and drive sustained weight loss when chronically activated, mechanistically distinguishing therapeutic appetite reduction from adverse GI effects.
Jiang, Wanqing; Skoug, Cecilia; Rodrigues, Ian; Ciabatti, Ernesto; Gribble, Fiona M; Reimann, Frank; Brierley, Daniel I; Holt, Marie K; Trapp, Stefan ·
Current oral peptide delivery strategies (NPs, lipids, permeation enhancers, enzyme inhibitors, targeted release) show progress but bioavailability remains typically <10%, requiring integrated multi-barrier approaches.
Jianghao, Zhang; Shadrack, Salumu Masuwa; Mingcheng, Wang; Shichao, Mi; Mengjia, Chu; Rakariyatham, Kanyasiri; McClements, David Julian; Chongjiang, Cao; Xiao, Xu; Biao, Yuan ·
Temporin-derived peptides: promoted MRSA wound healing, protected against lethal sepsis in mice, dual mechanism (membrane disruption + immunomodulation).
Jin, Xiao; Lan, Yawen; Wang, Rong; Wei, Shuangshuang; Song, Yanting; Hu, Wenting; Lyu, Junchen; Zhang, Yingxia ·
Case report of semaglutide early pregnancy exposure with literature review documenting pregnancy outcomes, contributing to limited but growing safety data for this increasingly common scenario.
Jin, Yuan-Cheng; Wu, Yu-Hua; Ma, Xue-Song; Shi, Wen; Wu, Miao-Lian; Hu, Qing-Qing ·
mSshep 1 from S. schlegelii: broad-spectrum antimicrobial (bacteria, fungi, parasites) combined with anti-inflammatory properties, demonstrating dual-function host defense peptide activity.
Jing, Hao; Wang, Guang-Hua; Yang, Kai; Chen, Zi-Yue; Zhu, Zhi-Shu; Sun, Nuo; Du, Yi-Lin; Wang, Zi-Qi; Zhang, Min ·
Antisense peptide-morpholino targeting ermC gene silenced antibiotic resistance in S. aureus, restoring erythromycin activity — demonstrating gene-specific antibiotic rescue strategy.
Jire, Piyush J; Sen, Vikram; Bharathwaj, Yashwanth; Ramesh, Arati ·
β-defensin-3 mimetic peptide: disrupted biofilms + modulated host-biofilm immune interactions, providing dual antimicrobial-immunomodulatory action for biofilm-associated infections.
Jo, Beom Soo; Lee, Dong Woo; Lee, Ji-Young; Seok, Sanghui; Kim, Yu-Bin; Lee, Jue-Yeon; Park, Shin-Young; Cho, Young Dan; Seol, Yang Jo; Park, Yoon Shin; Ghanaati, Shahram; Zadeh, Homayoun H; Chung, Chong Pyung; Park, Yoon Jeong ·
CRISPR/Cas9-engineered Salmonella phage displaying LL-37: combined phage lysis + AMP membrane disruption for enhanced dual-mechanism bacterial killing.
Jo, Su Jin; Park, Se Chang; Kim, Sang Guen ·
GLP-1 RA use associated with improved liver-related outcomes: reduced progression, fewer complications, and potential mortality benefit in chronic liver disease patients.
John, Binu V; Bastaich, Dustin; Marchetti, Daniella; Perumalswami, Ponni; Mustafa, Mixael Zirio; Dahman, Bassam ·
Novel 68Ga-labeled GRPR-targeted peptide PET tracers with improved tumor imaging for prostate/breast cancer through optimized peptide scaffold design.
Jozi, Shireen; Pathania, Sheetal; Wang, Lei; Chen, Chao-Cheng; Lau, Wing Sum; Ng, Pauline; Merkens, Helen; Bénard, François; Lin, Kuo-Shyan ·
Exendin-4 ameliorated D-galactose-induced hyposalivation in aging rats, likely through GLP-1R-mediated anti-inflammatory and anti-apoptotic protection of salivary gland tissue.
Jung, Jae-Eun; Park, Su-Bin; Yu, Hwa Young; Yoon, Su-Bin; Kim, Junghyun ·
Elevated serum CGRP levels associated with bacterial musculoskeletal infections in pediatric patients, showing potential as a complementary diagnostic biomarker alongside traditional inflammatory markers.
Kahane, Caroline G; Nigrovic, Lise E; Yang, Daping; Majzoub, Joseph A; Kellogg, Mark D; Kaplan, Ron L; Cruz, Andrea T; Chiu, Isaac M; Lyons, Todd W ·
GLP-1 cardiovascular protection: direct cardiac effects, anti-inflammatory mechanisms, vascular remodeling. Clinical trials establish GLP-1 drugs as cardiovascular therapeutics.
Kahles, Florian; Birkenfeld, Andreas L; Marx, Nikolaus ·
Glucose-lowering medications show distinct longitudinal effects on glucagon and GLP-1 levels, informing drug mechanism understanding and combination optimization.
Kahn, Steven E; Tripputi, Mark; Lachin, John M; Balasubramanyam, Ashok; Banerji, Mary Ann; Barzilay, Joshua; Cohen, Robert M; Garvey, W Timothy; Gramzinski, Michaela R; Rasouli, Neda; Rhee, Mary; Seegmiller, Jesse C; Singh, Vatsala; Sivitz, William I; Steffes, Michael W; Utzschneider, Kristina; DeFronzo, Ralph A ·
Photoreceptor-targeting peptides delivered gene therapy to modulate light avoidance in mice, demonstrating peptide-guided precision control of retinal function for photophobia treatment.
Kaiser, Eric A; Cavanah, Audrey; Aguirre, Geoffrey K; Jensen, Frances E ·
Incretin therapy (GLP-1 RAs) was not associated with increased self-harm behaviors in people with psychiatric conditions, providing safety reassurance.
Kalamaras, Hailey; White, Raechel T; Coon, Scott A; Perkel, Matthew; Elmaoued, Amre A ·
GLP-1 RAs had lower risk of adverse pancreatic events than SGLT2i and DPP-4i in comparative analysis, challenging the longstanding GLP-1 pancreatitis concern.
Kalathiya, Urja N; Herrin, Jeph; Swarna, Kavya Sindu; Deng, Yihong; Polley, Eric C; Neumiller, Joshua J; Galindo, Rodolfo J; Umpierrez, Guillermo E; Ross, Joseph S; Mickelson, Mindy M; McCoy, Rozalina G ·
Transient intestinal ischemia occurred in a semaglutide user, representing a rare but serious GI adverse event requiring clinical awareness.
Kalluru, Pavan Kumar Reddy; Cherukuri, Apoorva; Kuchi, Deekshitha; Topacio, Antonia ·
SGLT2i + GLP-1 RA: complementary cardiometabolic mechanisms; combined CV and renal benefits; growing evidence for early dual initiation in high-risk T2D patients.
Kalogeris, Aimilianos; Ikonomidis, Ignatios; Kyriakoulis, Konstantinos G; Pavlidis, George; Thymis, John; Katogiannis, Konstantinos; Kountouri, Aikaterini; Pliouta, Loukia; Pililis, Sotirios; Korakas, Emmanouil; Lambadiari, Vaia ·
HBD-3-functionalized Fe/GMP nanozyme: triple function — AMP direct killing + SOD/peroxidase mimicking antioxidant + wound healing promotion for comprehensive infection management.
Kamaraj, Yoganathan; Kumaresan, Veenayohini; Hu, Jinhao; Zhu, Daochen ·
Bidirectional GLP-1-microbiome interaction: gut bacteria modulate GLP-1 drug efficacy (SCFA production, inflammation modulation), while GLP-1 drugs reshape gut microbiome composition and function toward healthier profiles.
Kamath, Srinivas; Chan, Nicole S L; Joyce, Paul ·
Bone marrow NPY deficiency drives HSC aging with inflammation-biased differentiation and impaired hematopoiesis, revealing NPY as a niche-dependent regulator of blood stem cell function.
Kamble, Dinisha; Ropa, James P; Kamocka, Malgorzata M; Qi, Yan; Imperiale, Nick; Singh, Pratibha ·
Tirzepatide: significant HbA1c reduction and weight loss in T2D adults across clinical trial evidence, confirming dual metabolic efficacy.
Kamrul-Hasan, A B M; Chatterjee, Subhankar; Nagendra, Lakshmi; Dutta, Deep; Pappachan, Joseph M ·
IcoSema (weekly insulin icodec + semaglutide) showed non-inferior/superior glycemic and weight outcomes vs IDegLira (daily insulin degludec + liraglutide) in T2D.
Kandalam, Saikrishna; Benamar, Malik; Le Reun, Corinne; Rengger, Lauren; Gupta, Palvi; Nair, Sunita ·
Natural product + AMP combinations produce synergistic antimicrobial effects through complementary mechanisms, reducing effective doses and potentially circumventing resistance.
Kang, Ayue; Tian, Yue; Wang, Yan; Li, Xinhui; Xu, Shengnan; Yang, Ruige; Yang, Longhua; Guo, Yong ·
CAR-T cells and anticancer peptides as HCC therapies: peptides offer tumor selectivity, low immunogenicity, and engineering versatility; both approaches in clinical development.
Kannan, H Thamarai; Pan, Ieshita ·
Orforglipron: first non-peptide small-molecule oral GLP-1 RA with clinical efficacy for T2D and obesity; daily pill replacing injectable peptides; paradigm shift in GLP-1 therapy.
Kansakar, Urna; Jankauskas, Stanislovas S; Pande, Shivangi; Mone, Pasquale; Varzideh, Fahimeh; Santulli, Gaetano ·
Cyclodextrin-KR12 lipopeptide complexation: favorable thermodynamic binding with enthalpy and entropy contributions, potentially improving stability, solubility, and delivery of antimicrobial lipopeptides.
Kapica, Martyna; Grabowska, Ola; Kamysz, Elżbieta; Kamysz, Julia; Samsonov, Sergey A; Wyrzykowski, Dariusz ·
GLP-1 RAs and GLP-1/GIP/glucagon co-agonists associated with reduced atrial fibrillation risk in T2D and obesity through anti-inflammatory and cardiac remodeling mechanisms.
Karakasis, Paschalis; Vlachos, Konstantinos; Antoniadis, Antonios P; Siontis, Konstantinos C; Patoulias, Dimitrios; Fragakis, Nikolaos; Mantzoros, Christos S ·
Azurin from P. aeruginosa: anticancer via p53 stabilization, preferential tumor cell entry, angiogenesis inhibition. Peptide derivative p28 in clinical trials.
Karmanova, Ekaterina E; Goncharov, Ruslan G; Burmistrov, Dmitriy E; Chernikov, Anatoly V; Novoselov, Vladimir I; Sharapov, Mars G ·
GLP-1 RA fracture risk evaluated in older T2D adults, providing important safety data for this high-fracture-risk population experiencing significant drug-induced weight loss.
Kasher Meron, Michal; Hornik-Lurie, Tzipi; Twig, Gilad; Rotman-Pikielny, Pnina ·
GLP-1 RAs significantly reduce dementia risk in T2D patients in meta-analysis, with neuroprotective effects beyond glycemic control complementing other antidiabetic agents.
Kato, Sayaka; Ozu, Naoki; Yamakage, Hajime; Kato, Hisashi; Iuchi, Takujiro; Suzuki, Ryo; Noto, Hiroshi; Tanaka, Masashi; Fukui, Michiaki; Noda, Mitsuhiko; Satoh-Asahara, Noriko ·
GLP-1 RAs: consistent MACE reduction across diverse patient populations defined by age, sex, BMI, and cardiovascular risk profile.
Katz, Abigail; Nong, Yvonne; Ma, Elaine J; Roberts, Alyssa M; Chou, Peichi P; Jeong, Charlotte Y; Yan, Matthew J; Johnsen, Nicole; Armstrong, April W ·
Disproportionality signal detected for semaglutide-associated bile duct cancer in FAERS database, warranting further investigation while causation remains unestablished.
Kaur, Rimple Jeet; Gomaz, Simi Bridjit; Shaurya, Rekha; Aggarwal, Pravesh; Porchezhian, Pradakshna; Dhingra, Sameer; Sidhu, Preeti; Ambwani, Sneha; Charan, Jaykaran ·
Tachykinin neuropeptides may direct gonadotropin-independent follicular growth through evolutionarily conserved mechanisms, with implications for understanding early ovarian development and fertility.
Kawada, Tsuyoshi; Satake, Honoo ·
Novel dectin-1-binding peptides: developed for targeted dendritic cell antigen delivery, enabling precision vaccine design with improved immune activation.
Kawaguchi, Yoshirou; Sarker, Md Shahin; Yokoyama, Mina; Nakaya, Misuzu; Hosokawa, Takanatsu; Kamiya, Noriho; Goto, Masahiro ·
Serum HBD-2 significantly elevated in psoriasis and psoriatic arthritis vs controls, potentially serving as a biomarker for disease activity and systemic inflammation in autoimmune skin disease.
Kaya, Necip Enis; Kurmuş, Gökçe Işıl; Özdemirel, Ali Erhan; Altunay, Enes; Gönül, Müzeyyen ·
Scorpion Kv peptide in chitosan NPs: ameliorated D-galactose-induced tissue damage through anti-inflammatory and antioxidant mechanisms with improved delivery.
Kazemi-Lomedasht, Fatemeh; Eftekhari, Zohre; Chiani, Mohsen; Ramezanpour, Sorour; Montazeri, Ayda ·
Quadruple SGLT2i + GLP-1 RA + ARNI + MRA: comprehensive neurohormonal blockade targeting 4 distinct pathways for additive cardiorenal benefit in heart failure.
Ke, Jiahan; Qiu, Xiaohan; Wang, Min; Zeng, Huasu; Wang, Changqian; Zhang, Junfeng; Chen, Kan; Gu, Jun ·
NAION case associated with semaglutide use, adding to the pharmacovigilance evidence for this rare adverse event.
Kelly, A; Hasif, A; McAnena, L; O'Brien, C ·
Oncolytic peptides: multi-mechanism anticancer action including membrane disruption, immunogenic cell death, TME remodeling, and immune activation — resistant to typical cancer escape strategies.
Kepp, Oliver; Deng, Xiaolian; Xue, Enfu; Sveinbjørnsson, Baldur; Rekdal, Øystein; Galluzzi, Lorenzo; Kroemer, Guido ·
Localization-based motif combination produced AMPs with dual cell-penetrating + antimicrobial properties through systematic integration of functional motifs in peptide sequences.
Kesmen, Zülal; Batman, Saime Gülsüm; Canpolat, Melike; Büyükkiraz, Mine Erdem ·
Meal timing modulates ghrelin circadian rhythms through chrononutritional mechanisms, with implications for optimizing weight management and potentially complementing GLP-1 drug therapy.
Khaira, Fathiyyatul; Sulastri, Delmi ·
Molecularly targeted therapy reshapes DLBCL immunopeptidome, revealing novel tumor-specific MHC-presented peptides that could serve as targets for combination immunotherapy.
Khairkhah, Niloofar; Owolabi, Habeebah; Namvar, Ali; Ibrahim, Mostafa M H; Nyayapathy, Seeta; Jones, Richard; Rumble, Julie M; Whitehead, Christopher E; Sebolt-Leopold, Judith S; Everest-Dass, Arun; Galban, Stefanie ·
Multimodal HPLC stability-indicating methods: comprehensive semaglutide quality analysis identifying degradation products under thermal, photolytic, acid, base, and oxidative stress conditions.
Khalil, Hadeel A; Hassanein, Nermeen A; El-Yazbi, Amira F; Mahgoub, Hoda ·
Peptide-based QS disruption: prevents biofilm formation and virulence by blocking bacterial communication; reduces resistance risk vs bactericidal approaches; multiple strategies reviewed.
Khan, Mo Ahamad; Zhu, Lechen; Zhu, Hu ·
Comprehensive coverage of GLP-1, GIP, and glucagon receptor agonists: single (semaglutide), dual (tirzepatide), and triple (retatrutide) approaches with distinct metabolic profiles and expanding clinical evidence.
Khan, Mohammed Shareef; Bhutani, Utkarsh; Venugopal, Hariharan; Saini, Anuj Kumar; Naidu, Venkat Ramana; Kollipara, Sivacharan ·
CGRP antagonists for cluster headache: galcanezumab has strongest evidence (positive RCT for episodic CH); other agents mixed; safety acceptable but less data than for migraine; efficacy less robust than in migraine.
Khanfar, Ro'ya; Radwan, Eithar; Hattab, Sama ·
NPY modulates nicotine addiction through reward, stress, and feeding circuits. Emerging NPY-based therapeutics (receptor-specific agonists/antagonists) show potential for smoking cessation.
Khidkikar, Sameer; Malode, Divya; Taksande, Brijesh; Kale, Mayur; Taksande, Jayshree; Qutub, Mohammad; Tatode, Amol; Umekar, Milind ·
Nanoliposomal encapsulation: improved chia protein peptide stability, protected bioactivity, enhanced physicochemical properties for nutraceutical development.
Khushairay, Etty Syarmila Ibrahim; Yusop, Salma Mohamad; Maskat, Mohamad Yusof; Babji, Abdul Salam ·