Semaglutide in Early Pregnancy: Case Report and Literature Review of Outcomes | Research

The takeaway

A case report and literature review of semaglutide exposure in early pregnancy documented pregnancy outcomes, contributing to the limited safety data for this common clinical scenario.

Growing safety database
Each case of semaglutide pregnancy exposure adds to the limited safety data guiding risk counseling for millions of women

What the researchers found

Case report of semaglutide early pregnancy exposure with literature review documenting pregnancy outcomes, contributing to limited but growing safety data for this increasingly common scenario.

Why it matters

Millions of women of reproductive age take semaglutide. Understanding pregnancy exposure outcomes guides risk counseling.

How the study worked

Case report with systematic literature review of semaglutide early pregnancy exposure and outcomes.

What this study cannot tell us

Case-level evidence. Cannot establish safety definitively. Reporting bias toward adverse outcomes possible.

How to read the evidence

Case report with literature review — low evidence level but essential for safety database building.

When this study was published

Published in 2025.

The bigger picture

As GLP-1 drug use expands in women of reproductive age, pregnancy exposure data becomes critical for informed prescribing.

Questions still open

Should pregnancy testing be routine for semaglutide users?
How quickly should semaglutide be stopped when pregnancy is discovered?
Does the formulation (oral vs injectable) affect pregnancy risk?

Common questions

Is semaglutide dangerous during pregnancy?

The data is limited but growing. This case report adds to available evidence. Current guidance is to stop semaglutide before planned pregnancy and as soon as pregnancy is discovered.

What should I do if I get pregnant on semaglutide?

Stop semaglutide immediately and contact your obstetrician. Available evidence does not suggest high risk, but the data is still limited. Your doctor can provide personalized guidance.

Read the original research

Semaglutide exposure in early pregnancy and pregnancy outcomes: A case report and review of literature.

Journal of gynecology obstetrics and human reproduction, 55(4), 103133

View on PubMed ↗Publisher’s paper ↗

Citation

Jin, Yuan-Cheng; Wu, Yu-Hua; Ma, Xue-Song; Shi, Wen; Wu, Miao-Lian; Hu, Qing-Qing. (2026). Semaglutide exposure in early pregnancy and pregnancy outcomes: A case report and review of literature.. Journal of gynecology obstetrics and human reproduction, 55(4), 103133. https://doi.org/10.1016/j.jogoh.2026.103133