Browse more peptide research, methods and limitations.
RAMP3 interacts with the GLP-1 receptor, modifying its signaling profile and enhancing insulin secretion — findings later confirmed in the peer-reviewed publication.
Pearce, Abigail; Kumari, Poonam; Sisk, Claudia M; Harris, Matthew; Yeung, Ho Yan; Winfield, Sabrina; Caron, Kathleen M; Ladds, Graham · In Vitro
Four peptides from porcine liver and placenta (FWG, MFLG, SDPPLVFVG, FFNDA) demonstrated ACE-inhibitory activity, with placenta hydrolysate outperforming both liver hydrolysate and individual synthetic peptides.
Pearman, Nicholas A; Morris, Gordon A; Smith, Alan M · In Vitro
75-84% of tirzepatide responders sustained HbA1c ≤6.5% through median 81 weeks; predictors included higher dose, shorter diabetes duration, better baseline beta-cell function, and greater weight loss.
Pearson, Ewan R; Del Prato, Stefano; Pavo, Imre; Franco, Denise R; Zheng, Junyuan; Nicolay, Claudia; Hemmingway, Andrea; Wiese, Russell J; Kahn, Steven E · Secondary Analysis
While GLP-1 obesity medications are lifetime cost-effective, treating the 100+ million eligible US adults requires new market approaches and policy reforms to achieve affordable access.
Pearson, Steven D; Whaley, Christopher M; Emond, Sarah K · Policy Analysis
Marsupials have undergone lineage-specific cathelicidin gene expansions resulting in a large and diverse antimicrobial peptide repertoire distinct from placental mammals.
Peel, Emma; Gonsalvez, Adele; Hogg, Carolyn J; Belov, Katherine · In Vitro
The intramolecular disulfide bond in bovine lactoferricin transforms its molecular structure, which is essential for its antibacterial activity against four Gram-negative pathogenic bacteria.
Pei, Jie; Xiong, Lin; Wu, Xiaoyun; Chu, Min; Bao, Pengjia; Ge, Qianyun; Guo, Xian · In Vitro
Bladder-resident ILC3s develop trained immunity following uropathogenic E. coli exposure, enhancing their ability to defend against recurrent UTIs.
Pei, Qiaoqiao; Liu, Jiaqi; Tang, Ziwen; Tan, Jiaqing; Han, Xu; Hu, Xinrong; Liang, Zhou; Li, Feng; Zhu, Changjian; Lin, Ruoni; Zheng, Ruilin; Shen, Jiani; Liu, Qinghua; Mao, Haiping; Wu, Kefei; Chen, Wei; Zhou, Yi · Animal Study
Over 140,000 DDD of rimegepant were prescribed in Denmark by December 2024, with analysis of demographic characteristics, adherence patterns, and concomitant migraine therapy use.
Pellesi, Lanfranco; Do, Thien Phu; Ernst, Martin Thomsen; Hallas, Jesper; Pottegård, Anton · Observational
Multiple neurotransmitter and neuropeptide changes have been identified in cluster headache, but study results are inconsistent, highlighting gaps in understanding the neurochemical basis of attacks.
Pellesi, Lanfranco; Mohammad, Anas; Wang, Wei; Martelletti, Paolo · Systematic Review
Peripheral and central neurotransmitter alterations are present in tension-type headache but evidence remains inconsistent across studies, limiting therapeutic target identification.
Pellesi, Lanfranco; Yangjeh, Aidin; Hajjaj, Ibrahim; Lababidi, Mousbah; Sarwar, Fezan; Wang, Wei; Martelletti, Paolo · Systematic Review
The failure of NK-1 receptor antagonists does not necessarily mean substance P is irrelevant to migraine; a systematic re-evaluation using validated methodologies (like those used for CGRP) is warranted.
Pellesi, Lanfranco; Edvinsson, Lars · Narrative Review
Cardiorenal involvement is a major driver of morbidity and mortality in systemic sclerosis, with CKD commonly present at PAH diagnosis and independently associated with mortality.
Pellicano, Chiara; D'Ippolito, Giancarlo; Villa, Annalisa; Martellucci, Ottavio; Basile, Umberto; Carnazzo, Valeria; Basile, Valerio; Rosato, Edoardo; Marino, Mariapaola; Gigante, Antonietta · Narrative Review
Combining in vivo phage display with microdialysis-based parenchymal recovery enables selection of peptides capable of both vascular homing and tissue penetration.
Pemmari, Toini; Prince, Stuart; Wiss, Niklas; Kõiv, Kuldar; May, Ulrike; Mölder, Tarmo; Sudakov, Aleksander; Munoz Caro, Fernanda; Lehtonen, Soili; Uusitalo-Järvinen, Hannele; Teesalu, Tambet; Järvinen, Tero Ah · Animal Study
Neurogenic inflammation driven by substance P and CGRP from ingrowing nociceptive nerve fibers plays a crucial role in intervertebral disc degeneration, with non-neuronal cells also contributing.
Peng, Bao-Gan; Li, Yong-Chao; Yang, Liang · Narrative Review
IDO1-dependent tryptophan metabolites and endocan showed potential as effective diagnostic biomarkers for pregnancy-associated pulmonary hypertension.
Peng, Guixin; Liu, Zhuanghua; Wang, Wenli · Observational
Supplementing 0.2% soybean bioactive peptide in broiler feed improved intestinal health and metabolic function, revealed through multi-omics analysis of gut microbiome and metabolome.
Peng, Han; Song, Xiaoyan; Chen, Jialei; Xiong, Xia; Yang, Li; Yu, Chunlin; Qiu, Mohan; Zhang, Zengrong; Hu, Chenming; Zhu, Shiliang; Xia, Bo; Wang, Jiangxian; Xiong, Zhuxiang; Du, Longhuan; Yang, Chaowu · Animal Study
Sequence permutation of lysine/tryptophan-rich AMPs generated variants with enhanced therapeutic index, addressing key limitations of clinical antimicrobial peptide application.
Peng, Kuang-Li; Wu, Yu-Hsuan; Hsu, Hsuan-Che; Cheng, Jya-Wei · In Vitro
Hydrocarbon stapling of panurgine peptides from bee venom enhanced their stability, cell membrane permeability, and anti-breast cancer efficacy compared to linear counterparts.
Peng, Zhongzhong; Chen, Lei; Miao, Xianyuan; Wang, Qiongqiong; Fu, Shuyue; Zhang, Xikai; Zhou, Xiao; Ren, Sijia; Lao, Yehua; Li, Yinghua; Wang, Kaifeng; He, Shipeng · In Vitro
HbA1c, UACR, and systolic blood pressure only partially mediate GLP-1 RA cardiovascular benefits, with time-varying effects that differ between liraglutide and semaglutide and across patient subgroups.
Peng, Zi-Yang; Lee, Yu-Hsuan; Ou, Huang-Tz; Kuo, Shihchen · Secondary Analysis
Cost-effectiveness modeling for obesity pharmacotherapies faces unique challenges from interacting uncertainties: short trial durations, weight regain patterns, and complex relationships between weight loss and long-term cardiometabolic outcomes.
Pennington, Becky; Cummins, Ewen; Chandler, Albany; Fotheringham, James · Narrative Review
Silk fibroin sponges successfully loaded with FK-16 and GF-17 antimicrobial peptides showed sustained release properties suitable for local control of orthopedic implant infections.
Pennone, Vincenzo; Meogrossi, Giada; Carenzi, Giacomo; Sarlah, David; Biagiotti, Marco; Lovati, Arianna B · In Vitro
Single and repeated binge ethanol withdrawal in adolescent rats produced sex-dependent effects on social anxiety-like behavior and neuropeptide gene expression.
Penta, Peter T; Villarreal, Susanna; Rameas, Caitlin I; Collins, Ella C; Towner, Trevor T; Varlinskaya, Elena I; Werner, David F · Animal Study
Guanidinium-stapling provides a modular, solid-phase-compatible method for constraining helical peptides, with the guanidinium group potentially enhancing target binding at protein-protein interfaces.
Perdriau, Camille; Luton, Anaïs; Zimmeter, Katharina; Neuville, Maxime; Saragaglia, Claire; Peluso-Iltis, Carole; Osz, Judit; Kauffmann, Brice; Collie, Gavin W; Rochel, Natacha; Guichard, Gilles; Pasco, Morgane · In Vitro
First proteomic and peptidomic characterization of R. guttatus skin secretion identified proteins and peptides with similarities to known toad venoms and potential biological activities.
Pereira Dos Santos, Natalia Gabrielly; Mendes, Laís Campelo; Juliano, Maria Aparecida; Caldeira, Cleópatra Alves da Silva; Beraldo-Neto, Emídio; Pimenta, Daniel Carvalho · In Vitro
Large propensity-matched retrospective analysis compared perioperative GLP-1 RA users with non-users following lower extremity fracture fixation with two-year follow-up.
Pereira, Daniel E; Tummala, Sri; Mittal, Mehul M; Obey, Mitchel; Berkes, Marschall B; McAndrew, Christopher M; Wilson, Jenna L · Retrospective Cohort
Weight loss interventions including lifestyle modification, bariatric surgery, and GLP-1 receptor agonists can improve obesity-related male reproductive dysfunction through multiple mechanisms.
Pereira, Thairo A; Thaker, Niral; Rubez, André C; Lima, Victor F N; Bernie, Helen L; Esteves, Sandro C · Narrative Review
GLP-1 receptor agonists show potential nephroprotective effects in type 2 diabetes, including improvements in eGFR and albuminuria, though dedicated renal outcome studies are limited.
Perencin, Alessandro; Ceolin, Chiara; Papa, Mario V; DI Marzio, Benedetta; Zanforlini, Bruno M; Devita, Maria; Curreri, Chiara; Gasparini, Giulia; Sergi, Giuseppe; DE Rui, Marina · Systematic Review
PI3Kα and PI3Kβ inhibitors consistently increased cell death when combined with GHRH antagonist peptides MIA-602/690 across all prostate cancer types including androgen-resistant disease.
Perez-Stable, Carlos; de Las Pozas, Alicia; Wangpaichitr, Medhi; Sha, Wei; Wang, Haibo; Cai, Renzhi; Schally, Andrew V · In Vitro
Various structural modifications and delivery strategies have successfully overcome GLP-1's fragility, enabling the development of long-acting and orally available GLP-1 therapeutics.
Peri, Ravi Vamsi; Anchan, Harsh; Jonnalagadda, Kamal; Varghese, Ryan; Gupta, Pardeep · Narrative Review
GLP-1 receptor agonist use was associated with improved clinical outcomes following endovascular treatment of unruptured intracranial aneurysms in type 2 diabetes patients.
Perng, Pang-Shuo; Chang, Yu; Chuang, Ming-Tsung; Wong, Chia-En; Sun, Yuan-Ting; Wang, Hao-Kuang; Chi, Kuan-Yu; Lee, Jung-Shun; Wang, Liang-Chao; Huang, Chih-Yuan · Retrospective Cohort
Autopsy confirmed complete pathological remission of widely metastatic neuroendocrine cancer after just one cycle of [225Ac]Ac-DOTA-LM3 alpha-PRRT — a first in the literature.
Perrone, Elisabetta; Shaheen, Shagufta; Kunz, Pamela L; Henri, Heather C; Baum, Richard P · Case Report
35 patients received 57 cycles of [225Ac]Ac-DOTA-LM3 (alone or TANDEM with Lu-177) for resistant NEN, showing manageable safety and promising survival outcomes.
Perrone, Elisabetta; Calcagni, Maria Lucia; Leccisotti, Lucia; Moretti, Roberto; Ghai, Kriti; Eismant, Aleksandr; Parkar, Tanay; Greifenstein, Lukas; Baum, Richard Paul · Retrospective Cohort
TANDEM PRRT with Ac-225/Lu-177 labeled DOTA-LM3 (somatostatin receptor antagonist) achieved partial remission in all metastatic sites of a treatment-refractory pancreatic NEN with parotid metastasis.
Perrone, Elisabetta; Ghai, Kriti; Eismant, Aleksandr; Baum, Richard P · Case Report
GLP-1 RAs exert direct dermatological effects including potential benefits in inflammatory skin diseases, expanding their known therapeutic profile beyond metabolic applications.
Persson, Calista; Eaton, Allison; Mayrovitz, Harvey N · Systematic Review
Invertebrate innate immunity relies on diverse phagocytic cells and antimicrobial peptides that represent ancient, conserved defense mechanisms against pathogens.
Perveen, Nighat; Kishore, Uday; Al Aiyan, Ahmad; Willingham, Arve Lee; Mohteshamuddin, Khaja · Narrative Review
A composite hydrogel formulated from jellyfish collagen peptides and brown algae extract showed characteristics suitable for wound healing and skin repair applications.
Pesterau, Ana-Maria; Popescu, Antoanela; Sirbu, Rodica; Cadar, Emin; Busuricu, Florica; Dragan, Ana-Maria Laura; Pascale, Carolina; Ionescu, Ana-Maria; Bogdan-Andreescu, Claudia Florina; Radu, Marius-Daniel; Tomescu, Cezar Laurentiu · In Vitro
Profiling ~5,000 proteins revealed distinct biological pathways across HFpEF, HFmrEF, and HFrEF in diabetic patients, with exenatide modifying some proteomic signatures.
Peters, Anthony E; Nguyen, Maggie; Green, Jennifer B; Pearson, Ewan R; Buse, John B; Sourij, Harald; Hernandez, Adrian F; Sattar, Naveed; Holman, Rury R; Mentz, Robert J; Shah, Svati H · Secondary Analysis
Truncated tachykinin analogs retain receptor activity but show altered signaling bias at NK1R and NK2R, with the shortest functional versions being SP(6-11) and NKA(5-10).
Petersen, Jacob E; Pavlovskyi, Artem; Madsen, Jesper J; Schwartz, Thue W; Frimurer, Thomas M; Olsen, Ole H · In Vitro
AcHyA hydrogels functionalized with gelatin and antimicrobial peptide PP4-3.1 formed stable in situ gels that enhanced cellular responses while providing antimicrobial activity for chronic wounds.
Petit, Noémie; Gomes, Ana; Chang, Yu-Yin Joanne; Da Silva, Jessica; Leal, Ermelindo C; Carvalho, Eugénia; Gomes, Paula; Browne, Shane · In Vitro
Semaglutide reduced serum pro-inflammatory factors (CRP, cytokines, homocysteine) and improved psoriatic lesion severity in obese patients with type 2 diabetes.
Petković-Dabić, Jelena; Binić, Ivana; Carić, Bojana; Božić, Ljiljana; Umičević-Šipka, Sanja; Bednarčuk, Nataša; Dabić, Saša; Šitum, Mirna; Popović-Pejičić, Snježana; Stojiljković, Miloš P; Škrbić, Ranko · Randomized Controlled Trial
Liraglutide up to 3 mg daily failed to improve weight gain in a 3-year-old with tumor-related hypothalamic obesity from a brainstem ganglioglioma, despite good tolerability.
Petlansky, Rebecca; Graber, Evan · Case Report
Both oral and injectable semaglutide reduced liver inflammation, fibrosis markers, and oxidative stress in T2D patients with MASLD — the first oxidative stress data for semaglutide.
Petralli, Giovanni; Zoppo, Alice Del; Rovera, Chiara; Raggi, Francesco; Salvati, Antonio; Moriconi, Diego; Distaso, Mariarosaria; Brunetto, Maurizia Rossana; Solini, Anna · Observational
418 koala genomes revealed extensive intraspecific AMP diversity, with marsupial-specific cathelicidin gene expansions providing a large and varied antimicrobial peptide repertoire.
Petrohilos, Cleopatra; Peel, Emma; Silver, Luke W; Belov, Katherine; Hogg, Carolyn J · Computational
Semaglutide 2.4 mg/week achieved significant improvements in hepatic steatosis, MASH resolution, and fibrosis reduction in phase 2 and 3 trials, leading to conditional US approval.
Petta, Salvatore; Kim, KyeongJin; Targher, Giovanni; Romeo, Stefano; Sookoian, Silvia; Zheng, Ming-Hua; Aghemo, Alessio; Valenti, Luca · Narrative Review
New MASLD/MASH terminology improves diagnostic clarity, while semaglutide and newer agents offer the first effective pharmacological treatments for this common liver condition.
Peverelle, Matthew; Mbelle, Mzamo; Joshi, Deepak · Narrative Review
Youth ages 14-24 show widespread familiarity with semaglutide for weight loss, with complex attitudes influenced by social media, body image concerns, and potential vulnerability to weight-related discourse.
Peyyety, Vaishnavi; Jankowski, Margaret; Apte, Sarah; Sindelar, Jasmine; Elrajabi, Rawan; Chang, Tammy; Sonneville, Kendrin; Vajravelu, Mary Ellen · Cross Sectional
Somatostatin inhibited Aβ42 fibrillogenesis by 91% at 25 μM, outperforming its derivatives octreotide and lanreotide as well as the reference inhibitor orange G (86%).
Pham, Amy Trinh; Zhao, Yusheng; Oo, Amy; Hefny, Ahmed A; Ganesan, Aravindhan; Rao, Praveen P N · In Vitro
GLP1R rs6923761 GG homozygotes lost 1.64%/month vs. 1.02%/month for AA variants on semaglutide 2.4 mg; sex also influenced response, with women responding better.
Phan, Aurélie; Carette, Claire; Narjoz, Céline; Rives-Lange, Claire; Rassy, Nathalie; Czernichow, Sebastien; Pallet, Nicolas · Observational
Nano-biohybrids combining nanocarriers with cell-penetrating peptides show promise for crossing the BBB and delivering therapeutics to glioblastoma tumor cells.
Phatale, Vivek; Khairnar, Pooja; Shukla, Shalini; Puri, Niharika; Sahane, Prajakta; Srivastava, Saurabh · Narrative Review
GLP-1 receptor agonists and related hormone therapies can resolve MASH without worsening fibrosis, potentially preventing progression to liver cancer.
Phillips, Richard; Ma, Yuk Ting; Hanif, Wasim; Shah, Tahir; Sivakumar, Shivan · Narrative Review