Hydroxyproline-containing peptides from oral gelatin/collagen hydrolysate were detected in human blood, proving oral collagen peptides survive digestion and reach the bloodstream — validating collagen supplement bioavailability.
Key findingHydroxyproline-containing di- and tripeptides from orally ingested gelatin hydrolysate were detected in human plasma, with food-grade collagen hydroly
What the researchers found
Hydroxyproline-containing di- and tripeptides from orally ingested gelatin hydrolysate were detected in human plasma, with food-grade collagen hydrolysate producing higher peptide blood levels than gelatin — confirming oral collagen peptide bioavailability.
Why it matters
Relevant for collagen-peptides, bioavailability.
How the study worked
clinical-trial study on collagen-peptides, bioavailability.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources.
Journal of agricultural and food chemistry, 55(4), 1532-5
Citation
Ohara, Hiroki; Matsumoto, Hitoshi; Ito, Kyoko; Iwai, Koji; Sato, Kenji. (2007). Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources.. Journal of agricultural and food chemistry, 55(4), 1532-5.