Intranasal Neuropeptide Y as a Potential Therapeutic for Depressive Behavior in the Rodent Single Prolonged Stress Model in Females.
Quick Facts
What This Study Found
Female rats needed 1,200 μg intranasal NPY (4x male dose) to prevent SPS-induced depression. Combining 600 μg NPY + DPP4 inhibitor was equally effective.
Key Numbers
1,200 μg effective (4x male 300 μg); 600 μg alone ineffective; 600 μg + omarigliptin effective; prevented FST depression; tested at 19 days post-SPS
How They Did This
Sprague-Dawley female rats. SPS model. Multiple NPY doses tested intranasally after SPS. Behavioral testing at 19 days: forced swim, elevated plus maze, social interaction. DPP4 inhibitor combination tested.
Why This Research Matters
PTSD and depression disproportionately affect women. Understanding sex-specific dosing of neuropeptide therapies is essential for effective treatment.
What This Study Doesn't Tell Us
Rat model. SPS may not fully replicate human PTSD. Only one behavioral timepoint tested. Intranasal delivery in rats differs from humans.
Trust & Context
- Original Title:
- Intranasal Neuropeptide Y as a Potential Therapeutic for Depressive Behavior in the Rodent Single Prolonged Stress Model in Females.
- Published In:
- Frontiers in behavioral neuroscience, 15, 705579 (2021)
- Authors:
- Nahvi, Roxanna J, Tanelian, Arax, Nwokafor, Chiso, Hollander, Callie M, Peacock, Lauren, Sabban, Esther L
- Database ID:
- RPEP-05639
Evidence Hierarchy
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-05639APA
Nahvi, Roxanna J; Tanelian, Arax; Nwokafor, Chiso; Hollander, Callie M; Peacock, Lauren; Sabban, Esther L. (2021). Intranasal Neuropeptide Y as a Potential Therapeutic for Depressive Behavior in the Rodent Single Prolonged Stress Model in Females.. Frontiers in behavioral neuroscience, 15, 705579. https://doi.org/10.3389/fnbeh.2021.705579
MLA
Nahvi, Roxanna J, et al. "Intranasal Neuropeptide Y as a Potential Therapeutic for Depressive Behavior in the Rodent Single Prolonged Stress Model in Females.." Frontiers in behavioral neuroscience, 2021. https://doi.org/10.3389/fnbeh.2021.705579
RethinkPeptides
RethinkPeptides Research Database. "Intranasal Neuropeptide Y as a Potential Therapeutic for Dep..." RPEP-05639. Retrieved from https://rethinkpeptides.com/research/nahvi-2021-intranasal-neuropeptide-y-as
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.