A novel cell-permeable antioxidant peptide (SS-31 related) decreased renal tubular cell death and damage in a kidney obstruction model — expanding mitochondria-targeted peptides to kidney protection.
Key findingCell-permeable antioxidant peptide (SS-31 family) reduced renal tubular apoptosis, oxidative damage, and fibrosis in unilateral ureteral obstruction r
What the researchers found
Cell-permeable antioxidant peptide (SS-31 family) reduced renal tubular apoptosis, oxidative damage, and fibrosis in unilateral ureteral obstruction rats — expanding mitochondria-targeted peptide therapy to kidney protection for obstructive and other renal diseases.
Why it matters
Relevant for cell-penetrating, kidney, neuroprotection.
How the study worked
animal-study study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction.
American journal of physiology. Renal physiology, 295(5), F1545-53
Citation
Mizuguchi, Yasunori; Chen, Jie; Seshan, Surya V; Poppas, Dix P; Szeto, Hazel H; Felsen, Diane. (2008). A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction.. American journal of physiology. Renal physiology, 295(5), F1545-53. https://doi.org/10.1152/ajprenal.00395.2007