A Cell-Penetrating Antioxidant Peptide Protects Kidneys From Obstruction Damage
A novel cell-permeable antioxidant peptide (SS-31 related) decreased renal tubular cell death and damage in a kidney obstruction model — expanding mitochondria-targeted peptides to kidney protection.
Quick Facts
What This Study Found
Cell-permeable antioxidant peptide (SS-31 family) reduced renal tubular apoptosis, oxidative damage, and fibrosis in unilateral ureteral obstruction rats — expanding mitochondria-targeted peptide therapy to kidney protection for obstructive and other renal diseases.
Key Numbers
How They Did This
animal-study study.
Why This Research Matters
Relevant for cell-penetrating, kidney, neuroprotection.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Cell-permeable antioxidant peptide (SS-31 family) reduced renal tubular apoptosis, oxidative damage, and fibrosis in unilateral ureteral obstruction r
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction.
- Published In:
- American journal of physiology. Renal physiology, 295(5), F1545-53 (2008)
- Authors:
- Mizuguchi, Yasunori, Chen, Jie(6), Seshan, Surya V, Poppas, Dix P, Szeto, Hazel H, Felsen, Diane
- Database ID:
- RPEP-01387
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
A Cell-Penetrating Antioxidant Peptide Protects Kidneys From Obstruction Damage
What was found?
A novel cell-permeable antioxidant peptide (SS-31 related) decreased renal tubular cell death and damage in a kidney obstruction model — expanding mitochondria-targeted peptides to kidney protection.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01387APA
Mizuguchi, Yasunori; Chen, Jie; Seshan, Surya V; Poppas, Dix P; Szeto, Hazel H; Felsen, Diane. (2008). A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction.. American journal of physiology. Renal physiology, 295(5), F1545-53. https://doi.org/10.1152/ajprenal.00395.2007
MLA
Mizuguchi, Yasunori, et al. "A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction.." American journal of physiology. Renal physiology, 2008. https://doi.org/10.1152/ajprenal.00395.2007
RethinkPeptides
RethinkPeptides Research Database. "A novel cell-permeable antioxidant peptide decreases renal t..." RPEP-01387. Retrieved from https://rethinkpeptides.com/research/mizuguchi-2008-a-novel-cellpermeable-antioxidant
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.