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Oxytocin and Vasopressin Shape Human Social Brain Function: fMRI Evidence Review

ReviewModerate evidence
The takeaway

Intranasal oxytocin and vasopressin modulate human social brain function — amygdala, insula, prefrontal cortex — as shown by fMRI, with implications for treating autism, social anxiety, and other social cognition disorders.

Key finding

Intranasal oxytocin and vasopressin modulate human social brain circuits (amygdala fear, insula empathy, prefrontal evaluation) as demonstrated by fMR

What the researchers found

Intranasal oxytocin and vasopressin modulate human social brain circuits (amygdala fear, insula empathy, prefrontal evaluation) as demonstrated by fMRI — neuropeptide modulation of social cognition with therapeutic implications for autism and social anxiety.

Why it matters

Relevant for oxytocin, neuropeptides, anxiety-mood.

How the study worked

review study.

What this study cannot tell us

See abstract.

How to read the evidence

moderate evidence.

When this study was published

Published in 2008.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.
  • Clinical translation to evaluate.

Common questions

What was studied?
Oxytocin and Vasopressin Shape Human Social Brain Function: fMRI Evidence Review
What was found?
Intranasal oxytocin and vasopressin modulate human social brain function — amygdala, insula, prefrontal cortex — as shown by fMRI, with implications for treating autism, social anxiety, and other social cognition disorders.

Read the original research

Impact of prosocial neuropeptides on human brain function.

Progress in brain research, 170, 463-70

Citation

Meyer-Lindenberg, Andreas. (2008). Impact of prosocial neuropeptides on human brain function.. Progress in brain research, 170, 463-70. https://doi.org/10.1016/S0079-6123(08)00436-6