Bovine lactoferricin induced apoptosis of Listeria-infected human macrophages while sparing uninfected cells — selectively eliminating the infected cell reservoir to control intracellular infection.
Key findingLactoferricin B selectively induced apoptosis of Listeria monocytogenes-infected macrophages while sparing uninfected cells, eliminating the intracell
What the researchers found
Lactoferricin B selectively induced apoptosis of Listeria monocytogenes-infected macrophages while sparing uninfected cells, eliminating the intracellular bacterial reservoir — a selective anti-infection strategy targeting infected immune cells.
Why it matters
Relevant for antimicrobial-peptides, infection, immune-function.
How the study worked
in-vitro study on antimicrobial-peptides, infection.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Apoptotic death of Listeria monocytogenes-infected human macrophages induced by lactoferricin B, a bovine lactoferrin-derived peptide.
International journal of immunopathology and pharmacology, 18(2), 317-25
Citation
Longhi, C; Conte, M P; Ranaldi, S; Penta, M; Valenti, P; Tinari, A; Superti, F; Seganti, L. (2005). Apoptotic death of Listeria monocytogenes-infected human macrophages induced by lactoferricin B, a bovine lactoferrin-derived peptide.. International journal of immunopathology and pharmacology, 18(2), 317-25.