Bovine lactoferricin inhibited early infection events of Listeria monocytogenes in human macrophages, preventing bacterial entry and intracellular survival — a food safety relevant anti-virulence mechanism.
Key findingLactoferricin inhibited Listeria monocytogenes adhesion to and internalization by THP-1 human macrophages, reducing early infection events beyond dire
What the researchers found
Lactoferricin inhibited Listeria monocytogenes adhesion to and internalization by THP-1 human macrophages, reducing early infection events beyond direct bacterial killing — demonstrating anti-virulence protection.
Why it matters
Relevant for antimicrobial-peptides, infection, immune-function.
How the study worked
in-vitro study on antimicrobial-peptides, infection.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2004.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Lactoferricin influences early events of Listeria monocytogenes infection in THP-1 human macrophages.
Journal of medical microbiology, 53(Pt 2), 87-91
Citation
Longhi, Catia; Conte, Maria P; Penta, Michela; Cossu, Alessia; Antonini, Giovanni; Superti, Fabiana; Seganti, Lucilla. (2004). Lactoferricin influences early events of Listeria monocytogenes infection in THP-1 human macrophages.. Journal of medical microbiology, 53(Pt 2), 87-91. https://doi.org/10.1099/jmm.0.05367-0