Lactoferricin Blocks Early Steps of Listeria Infection in Human Immune Cells
Bovine lactoferricin inhibited early infection events of Listeria monocytogenes in human macrophages, preventing bacterial entry and intracellular survival — a food safety relevant anti-virulence mechanism.
Quick Facts
What This Study Found
Lactoferricin inhibited Listeria monocytogenes adhesion to and internalization by THP-1 human macrophages, reducing early infection events beyond direct bacterial killing — demonstrating anti-virulence protection.
Key Numbers
How They Did This
in-vitro study on antimicrobial-peptides, infection.
Why This Research Matters
Relevant for antimicrobial-peptides, infection, immune-function.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Lactoferricin inhibited Listeria monocytogenes adhesion to and internalization by THP-1 human macrophages, reducing early infection events beyond dire
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2004.
- Original Title:
- Lactoferricin influences early events of Listeria monocytogenes infection in THP-1 human macrophages.
- Published In:
- Journal of medical microbiology, 53(Pt 2), 87-91 (2004)
- Authors:
- Longhi, Catia, Conte, Maria P, Penta, Michela, Cossu, Alessia, Antonini, Giovanni, Superti, Fabiana, Seganti, Lucilla
- Database ID:
- RPEP-00943
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Lactoferricin Blocks Early Steps of Listeria Infection in Human Immune Cells
What was found?
Bovine lactoferricin inhibited early infection events of Listeria monocytogenes in human macrophages, preventing bacterial entry and intracellular survival — a food safety relevant anti-virulence mechanism.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-00943APA
Longhi, Catia; Conte, Maria P; Penta, Michela; Cossu, Alessia; Antonini, Giovanni; Superti, Fabiana; Seganti, Lucilla. (2004). Lactoferricin influences early events of Listeria monocytogenes infection in THP-1 human macrophages.. Journal of medical microbiology, 53(Pt 2), 87-91. https://doi.org/10.1099/jmm.0.05367-0
MLA
Longhi, Catia, et al. "Lactoferricin influences early events of Listeria monocytogenes infection in THP-1 human macrophages.." Journal of medical microbiology, 2004. https://doi.org/10.1099/jmm.0.05367-0
RethinkPeptides
RethinkPeptides Research Database. "Lactoferricin influences early events of Listeria monocytoge..." RPEP-00943. Retrieved from https://rethinkpeptides.com/research/longhi-2004-lactoferricin-influences-early-events
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.