Computationally predicted pentadecapeptides based on lactoferricin's active features were synthesized and showed real antimicrobial activity, validating computational approaches for designing antimicrobial peptide antibiotics.
Key findingNovel pentadecapeptides designed by computational prediction from lactoferricin's activity features demonstrated real antibacterial activity against t
What the researchers found
Novel pentadecapeptides designed by computational prediction from lactoferricin's activity features demonstrated real antibacterial activity against test organisms, validating in-silico antimicrobial peptide design approaches.
Why it matters
Advances understanding of antimicrobial-peptides, infection, peptide-design.
How the study worked
in-vitro study examining antimicrobial-peptides and infection.
What this study cannot tell us
Study-specific limitations; see abstract.
How to read the evidence
preliminary evidence from in-vitro study.
When this study was published
Published in 2004.
The bigger picture
Contributes to peptide research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation potential to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Prediction of antibiotic activity and synthesis of new pentadecapeptides based on lactoferricins.
Journal of peptide science : an official publication of the European Peptide Society, 10(6), 329-35
Citation
Lejon, Tore; Stiberg, Trine; Strøm, Morten B; Svendsen, John S. (2004). Prediction of antibiotic activity and synthesis of new pentadecapeptides based on lactoferricins.. Journal of peptide science : an official publication of the European Peptide Society, 10(6), 329-35.