Bariatric Surgery Transforms Gut Hormones Into an Appetite-Suppressing, Diabetes-Improving Profile
Bariatric surgery dramatically shifted gut hormone profiles toward an anorectic state — elevated GLP-1, PYY, oxyntomodulin with suppressed ghrelin — explaining both the weight loss and metabolic improvements post-surgery.
Quick Facts
What This Study Found
Bariatric surgery produced comprehensive gut hormone profile transformation: elevated GLP-1, PYY3-36, and oxyntomodulin with suppressed ghrelin, creating an anorectic hormonal milieu that facilitates weight loss and improves glucose metabolism beyond mechanical restriction.
Key Numbers
How They Did This
clinical-trial study on glp-1, weight-loss.
Why This Research Matters
Relevant for glp-1, weight-loss, diabetes.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Bariatric surgery produced comprehensive gut hormone profile transformation: elevated GLP-1, PYY3-36, and oxyntomodulin with suppressed ghrelin, creat
- Evidence Grade:
- strong evidence.
- Study Age:
- Published in 2006.
- Original Title:
- Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters.
- Published In:
- Annals of surgery, 243(1), 108-14 (2006)
- Authors:
- le Roux, Carel W(18), Aylwin, Simon J B, Batterham, Rachel L(3), Borg, Cynthia M, Coyle, Frances, Prasad, Vyas, Shurey, Sandra, Ghatei, Mohammad A, Patel, Ameet G, Bloom, Stephen R
- Database ID:
- RPEP-01161
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Bariatric Surgery Transforms Gut Hormones Into an Appetite-Suppressing, Diabetes-Improving Profile
What was found?
Bariatric surgery dramatically shifted gut hormone profiles toward an anorectic state — elevated GLP-1, PYY, oxyntomodulin with suppressed ghrelin — explaining both the weight loss and metabolic improvements post-surgery.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01161APA
le Roux, Carel W; Aylwin, Simon J B; Batterham, Rachel L; Borg, Cynthia M; Coyle, Frances; Prasad, Vyas; Shurey, Sandra; Ghatei, Mohammad A; Patel, Ameet G; Bloom, Stephen R. (2006). Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters.. Annals of surgery, 243(1), 108-14.
MLA
le Roux, Carel W, et al. "Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters.." Annals of surgery, 2006.
RethinkPeptides
RethinkPeptides Research Database. "Gut hormone profiles following bariatric surgery favor an an..." RPEP-01161. Retrieved from https://rethinkpeptides.com/research/le-2006-gut-hormone-profiles-following
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.