Plasma MMP-2, TIMP-1, and osteopontin levels correlated with BNP and heart failure severity, providing additional biomarkers of cardiac remodeling to complement natriuretic peptide-based assessment.
Key findingPlasma MMP-2, TIMP-1, and osteopontin correlated with BNP levels and heart failure severity, providing remodeling biomarkers complementing natriuretic
What the researchers found
Plasma MMP-2, TIMP-1, and osteopontin correlated with BNP levels and heart failure severity, providing remodeling biomarkers complementing natriuretic peptides — matrix markers capture the structural damage that peptide markers capture functionally.
Why it matters
Relevant for natriuretic-peptides, cardiovascular.
How the study worked
animal-study study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Plasma concentrations of matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-1 and osteopontin reflect severity of heart failure in DOCA-salt hypertensive rat.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 13(3), 270-81
Citation
Kramer, Frank; Sandner, Peter; Klein, Martina; Krahn, Thomas. (2008). Plasma concentrations of matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-1 and osteopontin reflect severity of heart failure in DOCA-salt hypertensive rat.. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 13(3), 270-81. https://doi.org/10.1080/13547500801903123