Lactoferrin and lactoferricin prevent herpes simplex virus infection by blocking viral attachment to cell surface heparan sulfate — a mechanism applicable to both prevention and treatment of herpes infections.
Key findingLactoferrin/lactoferricin anti-HSV activity operates through blocking viral attachment to cell surface heparan sulfate and potentially interfering wit
What the researchers found
Lactoferrin/lactoferricin anti-HSV activity operates through blocking viral attachment to cell surface heparan sulfate and potentially interfering with early infection events — applicable to both HSV-1 and HSV-2 with topical prevention implications.
Why it matters
Relevant for antimicrobial-peptides, infection.
How the study worked
review study on antimicrobial-peptides, infection.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Anti herpes simplex virus activity of lactoferrin/lactoferricin -- an example of antiviral activity of antimicrobial protein/peptide.
Cellular and molecular life sciences : CMLS, 62(24), 3002-13
Citation
Jenssen, H. (2005). Anti herpes simplex virus activity of lactoferrin/lactoferricin -- an example of antiviral activity of antimicrobial protein/peptide.. Cellular and molecular life sciences : CMLS, 62(24), 3002-13.