H. pylori eradication increased gastric ghrelin expression and was associated with increased appetite and body weight gain, explaining the weight gain commonly reported after successful H. pylori treatment.
Key findingH. pylori eradication restored gastric ghrelin expression and increased circulating ghrelin levels, correlating with increased appetite and BMI gain —
What the researchers found
H. pylori eradication restored gastric ghrelin expression and increased circulating ghrelin levels, correlating with increased appetite and BMI gain — providing the hormonal mechanism for the weight gain commonly observed after successful H. pylori treatment.
Why it matters
Relevant for neuropeptides, gut-healing.
How the study worked
clinical-trial study.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
The influence of the eradication of Helicobacter pylori on gastric ghrelin, appetite, and body mass index in patients with peptic ulcer disease.
Journal of gastroenterology and hepatology, 23 Suppl 2, S278-85
Citation
Jang, Eun Jeong; Park, Sang Woon; Park, Ju Sang; Park, Sang Jong; Hahm, Ki-Baik; Paik, So Ya; Sin, Mi Kyung; Lee, Eon Sook; Oh, Sang Woo; Park, Cheol Young; Baik, Hyun Wook. (2008). The influence of the eradication of Helicobacter pylori on gastric ghrelin, appetite, and body mass index in patients with peptic ulcer disease.. Journal of gastroenterology and hepatology, 23 Suppl 2, S278-85. https://doi.org/10.1111/j.1440-1746.2008.05415.x