CJC-1295 Clinical Trial: Single-Dose Injection Maintains Pulsatile GH for Days in Humans
A single dose of CJC-1295 (long-acting GHRH analog) maintained elevated pulsatile GH secretion for several days in healthy humans with dose-dependent duration — validating once-weekly or less frequent GH-axis restoration.
Quick Facts
What This Study Found
Single SC injection of CJC-1295 maintained elevated pulsatile GH secretion and IGF-1 for days in healthy subjects, with dose-dependent duration of action — validating once-weekly (or less) dosing for sustained GH-axis restoration in the first human clinical trial.
Key Numbers
How They Did This
clinical-trial study on cjc-1295, hormone-optimization.
Why This Research Matters
Relevant for cjc-1295, hormone-optimization.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Single SC injection of CJC-1295 maintained elevated pulsatile GH secretion and IGF-1 for days in healthy subjects, with dose-dependent duration of act
- Evidence Grade:
- strong evidence.
- Study Age:
- Published in 2006.
- Original Title:
- Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.
- Published In:
- The Journal of clinical endocrinology and metabolism, 91(12), 4792-7 (2006)
- Authors:
- Ionescu, Madalina, Frohman, Lawrence A(4)
- Database ID:
- RPEP-01148
Evidence Hierarchy
Frequently Asked Questions
What was studied?
CJC-1295 Clinical Trial: Single-Dose Injection Maintains Pulsatile GH for Days in Humans
What was found?
A single dose of CJC-1295 (long-acting GHRH analog) maintained elevated pulsatile GH secretion for several days in healthy humans with dose-dependent duration — validating once-weekly or less frequent GH-axis restoration.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01148APA
Ionescu, Madalina; Frohman, Lawrence A. (2006). Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.. The Journal of clinical endocrinology and metabolism, 91(12), 4792-7.
MLA
Ionescu, Madalina, et al. "Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.." The Journal of clinical endocrinology and metabolism, 2006.
RethinkPeptides
RethinkPeptides Research Database. "Pulsatile secretion of growth hormone (GH) persists during c..." RPEP-01148. Retrieved from https://rethinkpeptides.com/research/ionescu-2006-pulsatile-secretion-of-growth
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.