A single subcutaneous injection of CJC-1295 in healthy humans produced dose-dependent, sustained GH and IGF-1 elevation lasting up to 2 weeks — the longest-acting GH-axis restoration from a single peptide dose.
Key findingSingle SC CJC-1295 injection in healthy adults produced dose-dependent sustained GH pulsatility and IGF-1 elevation lasting 6-14 days depending on dos
What the researchers found
Single SC CJC-1295 injection in healthy adults produced dose-dependent sustained GH pulsatility and IGF-1 elevation lasting 6-14 days depending on dose, with 2-3 fold IGF-1 increase maintained for up to 2 weeks — the most sustained GH-axis restoration from a single peptide dose.
Why it matters
Relevant for cjc-1295, hormone-optimization.
How the study worked
RCT study on cjc-1295, hormone-optimization.
What this study cannot tell us
See abstract.
How to read the evidence
strong evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.
The Journal of clinical endocrinology and metabolism, 91(3), 799-805
Citation
Teichman, Sam L; Neale, Ann; Lawrence, Betty; Gagnon, Catherine; Castaigne, Jean-Paul; Frohman, Lawrence A. (2006). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.. The Journal of clinical endocrinology and metabolism, 91(3), 799-805.