Peripheral and Central Appetite Signals in Normal, Obese, and Binge-Eating People
Appetite control in normal, obese, and binge-eating individuals involves distinct patterns of peripheral (gut peptides, leptin) and central (hypothalamic) signal dysfunction — each eating disorder has its own signaling fingerprint.
Quick Facts
What This Study Found
Normal, obese, and binge-eating individuals show distinct patterns of appetite signal dysfunction across peripheral (gut peptides, adipokines) and central (hypothalamic neuropeptide) systems — disorder-specific signaling profiles enabling targeted treatment.
Key Numbers
How They Did This
review study examining glp-1 and neuropeptides.
Why This Research Matters
Advances understanding of glp-1, neuropeptides, weight-loss, receptor-signaling with translational implications.
The Bigger Picture
Contributes to the growing body of peptide research with implications for clinical development and therapeutic applications.
What This Study Doesn't Tell Us
Study-specific limitations apply; see abstract for details.
Questions This Raises
- ?Further research needed to confirm and extend these findings.
- ?Clinical translation and safety need evaluation.
- ?Optimal dosing and delivery require characterization.
Trust & Context
- Key Stat:
- Key finding Normal, obese, and binge-eating individuals show distinct patterns of appetite signal dysfunction across peripheral (gut peptides, adipokines) and cen
- Evidence Grade:
- moderate evidence from review study design.
- Study Age:
- Published in 2004.
- Original Title:
- Peripheral and central signals in the control of eating in normal, obese and binge-eating human subjects.
- Published In:
- The British journal of nutrition, 92 Suppl 1, S47-57 (2004)
- Authors:
- Hellström, Per M(2), Geliebter, Allan(2), Näslund, Erik(3), Schmidt, Peter T, Yahav, Eric K, Hashim, Sami A, Yeomans, Martin R
- Database ID:
- RPEP-00925
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was the main focus of this study?
Peripheral and Central Appetite Signals in Normal, Obese, and Binge-Eating People
What was discovered?
Appetite control in normal, obese, and binge-eating individuals involves distinct patterns of peripheral (gut peptides, leptin) and central (hypothalamic) signal dysfunction — each eating disorder has its own signaling fingerprint.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-00925APA
Hellström, Per M; Geliebter, Allan; Näslund, Erik; Schmidt, Peter T; Yahav, Eric K; Hashim, Sami A; Yeomans, Martin R. (2004). Peripheral and central signals in the control of eating in normal, obese and binge-eating human subjects.. The British journal of nutrition, 92 Suppl 1, S47-57.
MLA
Hellström, Per M, et al. "Peripheral and central signals in the control of eating in normal, obese and binge-eating human subjects.." The British journal of nutrition, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Peripheral and central signals in the control of eating in n..." RPEP-00925. Retrieved from https://rethinkpeptides.com/research/hellstrom-2004-peripheral-and-central-signals
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.