Soluble glycoprotein 130 (inflammatory marker) and BNP predicted heart failure progression over long-term follow-up but captured different disease aspects — inflammation versus hemodynamic stress — supporting multi-marker monitoring.
Key findingSoluble GP130 (IL-6 trans-signaling marker) and NT-proBNP both predicted heart failure progression over 2+ years but reflected different pathophysiolo
What the researchers found
Soluble GP130 (IL-6 trans-signaling marker) and NT-proBNP both predicted heart failure progression over 2+ years but reflected different pathophysiology: GP130 = inflammatory deterioration; BNP = hemodynamic stress — complementary long-term prognostic markers.
Why it matters
Relevant for natriuretic-peptides, cardiovascular, clinical-trials.
How the study worked
cohort study on natriuretic-peptides, cardiovascular.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Comparison of soluble glycoprotein 130 and cardiac natriuretic peptides as long-term predictors of heart failure progression.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 24(12), 2190-5
Citation
Gwechenberger, Marianne; Pacher, Richard; Berger, Rudolf; Zorn, Gerlinde; Moser, Petra; Stanek, Brigitte; Huelsmann, Martin. (2005). Comparison of soluble glycoprotein 130 and cardiac natriuretic peptides as long-term predictors of heart failure progression.. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 24(12), 2190-5.