VIP Regulates Human T-Cell Subsets Differently: Implications for Rheumatoid Arthritis Treatment
VIP (vasoactive intestinal peptide) differentially regulated human T-cell subsets — suppressing effector T-cells while supporting regulatory T-cells — with implications for restoring immune balance in rheumatoid arthritis.
Quick Facts
What This Study Found
VIP differentially modulated human T-cell subsets: suppressed CD4+ effector T-cell proliferation/activation while supporting CD4+CD25+ regulatory T-cell function and survival — directly applicable to restoring the effector/regulatory T-cell balance in rheumatoid arthritis.
Key Numbers
How They Did This
in-vitro study.
Why This Research Matters
Relevant for neuropeptides, inflammation, immune-function.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding VIP differentially modulated human T-cell subsets: suppressed CD4+ effector T-cell proliferation/activation while supporting CD4+CD25+ regulatory T-ce
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Immunoregulatory properties of vasoactive intestinal peptide in human T cell subsets: implications for rheumatoid arthritis.
- Published In:
- Brain, behavior, and immunity, 22(3), 312-7 (2008)
- Authors:
- Gutiérrez-Cañas, Irene, Juarranz, Yasmina(2), Santiago, Begoña, Martínez, Carmen, Gomariz, Rosa P, Pablos, José Luis, Leceta, Javier
- Database ID:
- RPEP-01348
Evidence Hierarchy
Frequently Asked Questions
What was studied?
VIP Regulates Human T-Cell Subsets Differently: Implications for Rheumatoid Arthritis Treatment
What was found?
VIP (vasoactive intestinal peptide) differentially regulated human T-cell subsets — suppressing effector T-cells while supporting regulatory T-cells — with implications for restoring immune balance in rheumatoid arthritis.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01348APA
Gutiérrez-Cañas, Irene; Juarranz, Yasmina; Santiago, Begoña; Martínez, Carmen; Gomariz, Rosa P; Pablos, José Luis; Leceta, Javier. (2008). Immunoregulatory properties of vasoactive intestinal peptide in human T cell subsets: implications for rheumatoid arthritis.. Brain, behavior, and immunity, 22(3), 312-7.
MLA
Gutiérrez-Cañas, Irene, et al. "Immunoregulatory properties of vasoactive intestinal peptide in human T cell subsets: implications for rheumatoid arthritis.." Brain, 2008.
RethinkPeptides
RethinkPeptides Research Database. "Immunoregulatory properties of vasoactive intestinal peptide..." RPEP-01348. Retrieved from https://rethinkpeptides.com/research/gutierrez-canas-2008-immunoregulatory-properties-of-vasoactive
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.