Synthetic nisin analogs made by ring-closing metathesis showed antimicrobial activity, demonstrating that chemical synthesis can replicate and improve upon this important natural cyclic peptide antibiotic.
Key findingBicyclic nisin analogs synthesized via ring-closing metathesis retained antimicrobial activity against gram-positive bacteria, validating chemical syn
What the researchers found
Bicyclic nisin analogs synthesized via ring-closing metathesis retained antimicrobial activity against gram-positive bacteria, validating chemical synthesis approaches for producing and optimizing this clinically important natural cyclic peptide antibiotic.
Why it matters
Relevant for antimicrobial-peptides, peptide-design, infection.
How the study worked
in-vitro study on antimicrobial-peptides, peptide-design.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Synthesis of bicyclic alkene-/alkane-bridged nisin mimics by ring-closing metathesis and their biochemical evaluation as lipid II binders: toward the design of potential novel antibiotics.
Chembiochem : a European journal of chemical biology, 8(13), 1540-54
Citation
Ghalit, Nourdin; Reichwein, John F; Hilbers, Hans W; Breukink, Eefjan; Rijkers, Dirk T S; Liskamp, Rob M J. (2007). Synthesis of bicyclic alkene-/alkane-bridged nisin mimics by ring-closing metathesis and their biochemical evaluation as lipid II binders: toward the design of potential novel antibiotics.. Chembiochem : a European journal of chemical biology, 8(13), 1540-54.