Creating Synthetic Versions of the Natural Antibiotic Nisin: Ring-Closing Chemistry Approach
Synthetic nisin analogs made by ring-closing metathesis showed antimicrobial activity, demonstrating that chemical synthesis can replicate and improve upon this important natural cyclic peptide antibiotic.
Quick Facts
What This Study Found
Bicyclic nisin analogs synthesized via ring-closing metathesis retained antimicrobial activity against gram-positive bacteria, validating chemical synthesis approaches for producing and optimizing this clinically important natural cyclic peptide antibiotic.
Key Numbers
How They Did This
in-vitro study on antimicrobial-peptides, peptide-design.
Why This Research Matters
Relevant for antimicrobial-peptides, peptide-design, infection.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Bicyclic nisin analogs synthesized via ring-closing metathesis retained antimicrobial activity against gram-positive bacteria, validating chemical syn
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2007.
- Original Title:
- Synthesis of bicyclic alkene-/alkane-bridged nisin mimics by ring-closing metathesis and their biochemical evaluation as lipid II binders: toward the design of potential novel antibiotics.
- Published In:
- Chembiochem : a European journal of chemical biology, 8(13), 1540-54 (2007)
- Authors:
- Ghalit, Nourdin, Reichwein, John F, Hilbers, Hans W, Breukink, Eefjan, Rijkers, Dirk T S, Liskamp, Rob M J
- Database ID:
- RPEP-01231
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Creating Synthetic Versions of the Natural Antibiotic Nisin: Ring-Closing Chemistry Approach
What was found?
Synthetic nisin analogs made by ring-closing metathesis showed antimicrobial activity, demonstrating that chemical synthesis can replicate and improve upon this important natural cyclic peptide antibiotic.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01231APA
Ghalit, Nourdin; Reichwein, John F; Hilbers, Hans W; Breukink, Eefjan; Rijkers, Dirk T S; Liskamp, Rob M J. (2007). Synthesis of bicyclic alkene-/alkane-bridged nisin mimics by ring-closing metathesis and their biochemical evaluation as lipid II binders: toward the design of potential novel antibiotics.. Chembiochem : a European journal of chemical biology, 8(13), 1540-54.
MLA
Ghalit, Nourdin, et al. "Synthesis of bicyclic alkene-/alkane-bridged nisin mimics by ring-closing metathesis and their biochemical evaluation as lipid II binders: toward the design of potential novel antibiotics.." Chembiochem : a European journal of chemical biology, 2007.
RethinkPeptides
RethinkPeptides Research Database. "Synthesis of bicyclic alkene-/alkane-bridged nisin mimics by..." RPEP-01231. Retrieved from https://rethinkpeptides.com/research/ghalit-2007-synthesis-of-bicyclic-alkenealkanebridged
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.