KPV Dimer (CKPV)2 Blocks Endotoxin-Induced Inflammation in Mice
The dimeric KPV peptide (CKPV)2 potently inhibited LPS-induced inflammatory responses in mice, including fever, cytokine release, and organ damage — demonstrating enhanced anti-inflammatory efficacy from the dimerized KPV scaffold.
Quick Facts
What This Study Found
Dimeric KPV peptide (CKPV)2 inhibited endotoxin-induced host responses including fever, TNF-α/IL-6 release, and organ damage in mice, with enhanced anti-inflammatory potency compared to monomeric alpha-MSH — demonstrating improved efficacy through KPV dimerization.
Key Numbers
How They Did This
animal-study study on kpv, inflammation.
Why This Research Matters
Relevant for kpv, inflammation, infection.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Dimeric KPV peptide (CKPV)2 inhibited endotoxin-induced host responses including fever, TNF-α/IL-6 release, and organ damage in mice, with enhanced an
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2006.
- Original Title:
- Inhibitory effects of the peptide (CKPV)2 on endotoxin-induced host reactions.
- Published In:
- The Journal of surgical research, 131(2), 209-14 (2006)
- Authors:
- Gatti, Stefano, Carlin, Andrea, Sordi, Andrea, Leonardi, Patrizia, Colombo, Gualtiero, Fassati, Luigi R, Lipton, James M, Catania, Anna
- Database ID:
- RPEP-01138
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
KPV Dimer (CKPV)2 Blocks Endotoxin-Induced Inflammation in Mice
What was found?
The dimeric KPV peptide (CKPV)2 potently inhibited LPS-induced inflammatory responses in mice, including fever, cytokine release, and organ damage — demonstrating enhanced anti-inflammatory efficacy from the dimerized KPV scaffold.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01138APA
Gatti, Stefano; Carlin, Andrea; Sordi, Andrea; Leonardi, Patrizia; Colombo, Gualtiero; Fassati, Luigi R; Lipton, James M; Catania, Anna. (2006). Inhibitory effects of the peptide (CKPV)2 on endotoxin-induced host reactions.. The Journal of surgical research, 131(2), 209-14.
MLA
Gatti, Stefano, et al. "Inhibitory effects of the peptide (CKPV)2 on endotoxin-induced host reactions.." The Journal of surgical research, 2006.
RethinkPeptides
RethinkPeptides Research Database. "Inhibitory effects of the peptide (CKPV)2 on endotoxin-induc..." RPEP-01138. Retrieved from https://rethinkpeptides.com/research/gatti-2006-inhibitory-effects-of-the
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.