Producing a Thymosin Alpha-1 and Thymopentin Fusion Peptide in Yeast for Dual Immune Enhancement
A fusion peptide combining thymosin alpha-1 and thymopentin (TP-5) was expressed in Pichia pastoris with dual immunostimulatory activity — combining two thymic peptides for enhanced immune modulation from a single molecule.
Quick Facts
What This Study Found
Thymosin alpha-1-thymopentin fusion peptide expressed in P. pastoris retained both components' immunostimulatory activities, creating a dual-function immune peptide combining T-cell modulation (TA1) with thymocyte maturation (TP-5) in a single recombinant molecule.
Key Numbers
How They Did This
in-vitro study.
Why This Research Matters
Relevant for thymosin-alpha-1, peptide-design, immune-function.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Thymosin alpha-1-thymopentin fusion peptide expressed in P. pastoris retained both components' immunostimulatory activities, creating a dual-function
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Expression of thymosin alpha1-thymopentin fusion peptide in Pichia pastoris and its characterization.
- Published In:
- Archives of pharmacal research, 31(11), 1471-6 (2008)
- Authors:
- Gao, Demin, Zhang, Xulong, Zhang, Jian(5), Cao, Jichao, Wang, Fengshan
- Database ID:
- RPEP-01341
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Producing a Thymosin Alpha-1 and Thymopentin Fusion Peptide in Yeast for Dual Immune Enhancement
What was found?
A fusion peptide combining thymosin alpha-1 and thymopentin (TP-5) was expressed in Pichia pastoris with dual immunostimulatory activity — combining two thymic peptides for enhanced immune modulation from a single molecule.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01341APA
Gao, Demin; Zhang, Xulong; Zhang, Jian; Cao, Jichao; Wang, Fengshan. (2008). Expression of thymosin alpha1-thymopentin fusion peptide in Pichia pastoris and its characterization.. Archives of pharmacal research, 31(11), 1471-6. https://doi.org/10.1007/s12272-001-2132-z
MLA
Gao, Demin, et al. "Expression of thymosin alpha1-thymopentin fusion peptide in Pichia pastoris and its characterization.." Archives of pharmacal research, 2008. https://doi.org/10.1007/s12272-001-2132-z
RethinkPeptides
RethinkPeptides Research Database. "Expression of thymosin alpha1-thymopentin fusion peptide in ..." RPEP-01341. Retrieved from https://rethinkpeptides.com/research/gao-2008-expression-of-thymosin-alpha1thymopentin
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.