Engineering a Thymosin Alpha-1 Fusion Protein for Enhanced Immune Stimulation
A fusion protein combining thymosin alpha-1 with B-lymphocyte stimulator (BLyS) was expressed in E. coli, potentially combining T-cell and B-cell immune enhancement in a single molecule for comprehensive immunotherapy.
Quick Facts
What This Study Found
Thymosin alpha-1-cBLyS fusion protein expressed in E. coli combined T-cell immune enhancement (thymosin alpha-1) with B-cell stimulation (BLyS), creating a dual-arm immunostimulatory molecule for potential comprehensive immunotherapy.
Key Numbers
How They Did This
in-vitro study on thymosin-alpha-1, immune-function.
Why This Research Matters
Relevant for thymosin-alpha-1, immune-function, peptide-design.
The Bigger Picture
Advances peptide/biomarker research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Thymosin alpha-1-cBLyS fusion protein expressed in E. coli combined T-cell immune enhancement (thymosin alpha-1) with B-cell stimulation (BLyS), creat
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2005.
- Original Title:
- Construction and expression of a new fusion protein, thymosin alpha1-cBLyS, E. coli.
- Published In:
- Biotechnology letters, 27(3), 143-8 (2005)
- Authors:
- Shen, Qiong, Tian, Ruiyang, Ma, Wenzhe(2), Yuan, Qinsheng, Gong, Yi
- Database ID:
- RPEP-01083
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Engineering a Thymosin Alpha-1 Fusion Protein for Enhanced Immune Stimulation
What was found?
A fusion protein combining thymosin alpha-1 with B-lymphocyte stimulator (BLyS) was expressed in E. coli, potentially combining T-cell and B-cell immune enhancement in a single molecule for comprehensive immunotherapy.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01083APA
Shen, Qiong; Tian, Ruiyang; Ma, Wenzhe; Yuan, Qinsheng; Gong, Yi. (2005). Construction and expression of a new fusion protein, thymosin alpha1-cBLyS, E. coli.. Biotechnology letters, 27(3), 143-8.
MLA
Shen, Qiong, et al. "Construction and expression of a new fusion protein, thymosin alpha1-cBLyS, E. coli.." Biotechnology letters, 2005.
RethinkPeptides
RethinkPeptides Research Database. "Construction and expression of a new fusion protein, thymosi..." RPEP-01083. Retrieved from https://rethinkpeptides.com/research/shen-2005-construction-and-expression-of
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.