Both Ghrelin AND Des-Acyl Ghrelin Stimulate Adrenal Cancer Cell Growth
Both acylated ghrelin and des-acyl ghrelin stimulated adrenocortical tumor cell proliferation through anti-apoptotic pathways, confirming the ghrelin system promotes growth in at least some cancer types regardless of acylation status.
Quick Facts
What This Study Found
Both ghrelin and des-acyl ghrelin stimulated adrenocortical tumor cell proliferation via anti-apoptotic pathway activation (reduced caspase-3, increased Bcl-2), demonstrating pro-tumorigenic ghrelin system activity in adrenal cancer regardless of GHS-R1a-dependent signaling.
Key Numbers
How They Did This
in-vitro study on ghrp, cancer.
Why This Research Matters
Relevant for ghrp, cancer, hormone-optimization.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Both ghrelin and des-acyl ghrelin stimulated adrenocortical tumor cell proliferation via anti-apoptotic pathway activation (reduced caspase-3, increas
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2007.
- Original Title:
- Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway.
- Published In:
- American journal of physiology. Endocrinology and metabolism, 293(1), E302-9 (2007)
- Authors:
- Delhanty, P J D, van Koetsveld, P M, Gauna, C(2), van de Zande, B, Vitale, G, Hofland, L J, van der Lely, A J
- Database ID:
- RPEP-01218
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Both Ghrelin AND Des-Acyl Ghrelin Stimulate Adrenal Cancer Cell Growth
What was found?
Both acylated ghrelin and des-acyl ghrelin stimulated adrenocortical tumor cell proliferation through anti-apoptotic pathways, confirming the ghrelin system promotes growth in at least some cancer types regardless of acylation status.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01218APA
Delhanty, P J D; van Koetsveld, P M; Gauna, C; van de Zande, B; Vitale, G; Hofland, L J; van der Lely, A J. (2007). Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway.. American journal of physiology. Endocrinology and metabolism, 293(1), E302-9.
MLA
Delhanty, P J D, et al. "Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway.." American journal of physiology. Endocrinology and metabolism, 2007.
RethinkPeptides
RethinkPeptides Research Database. "Ghrelin and its unacylated isoform stimulate the growth of a..." RPEP-01218. Retrieved from https://rethinkpeptides.com/research/delhanty-2007-ghrelin-and-its-unacylated
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.