Both acylated ghrelin and des-acyl ghrelin stimulated adrenocortical tumor cell proliferation through anti-apoptotic pathways, confirming the ghrelin system promotes growth in at least some cancer types regardless of acylation status.
Key findingBoth ghrelin and des-acyl ghrelin stimulated adrenocortical tumor cell proliferation via anti-apoptotic pathway activation (reduced caspase-3, increas
What the researchers found
Both ghrelin and des-acyl ghrelin stimulated adrenocortical tumor cell proliferation via anti-apoptotic pathway activation (reduced caspase-3, increased Bcl-2), demonstrating pro-tumorigenic ghrelin system activity in adrenal cancer regardless of GHS-R1a-dependent signaling.
Why it matters
Relevant for ghrp, cancer, hormone-optimization.
How the study worked
in-vitro study on ghrp, cancer.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway.
American journal of physiology. Endocrinology and metabolism, 293(1), E302-9
Citation
Delhanty, P J D; van Koetsveld, P M; Gauna, C; van de Zande, B; Vitale, G; Hofland, L J; van der Lely, A J. (2007). Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway.. American journal of physiology. Endocrinology and metabolism, 293(1), E302-9.