Ghrelin Promotes Adrenal Cell Growth Through MAPK Signaling and Inhibits Apoptosis
Ghrelin enhanced adrenal zona glomerulosa cell proliferation through MAPK pathway activation while also inhibiting apoptosis, revealing dual growth-promoting effects on adrenal tissue through functional GHS receptors.
Quick Facts
What This Study Found
Ghrelin stimulated human adrenal zona glomerulosa cell proliferation via p42/p44 MAPK activation and simultaneously inhibited apoptosis through functional GHS-R — dual proliferogenic and anti-apoptotic adrenal effects.
Key Numbers
How They Did This
in-vitro study on ghrp, hormone-optimization.
Why This Research Matters
Relevant for ghrp, hormone-optimization, cancer, receptor-signaling.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Ghrelin stimulated human adrenal zona glomerulosa cell proliferation via p42/p44 MAPK activation and simultaneously inhibited apoptosis through functi
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2004.
- Original Title:
- Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects.
- Published In:
- Peptides, 25(8), 1269-77 (2004)
- Authors:
- Mazzocchi, Giuseppina, Neri, Giuliano, Rucinski, Marcin, Rebuffat, Piera, Spinazzi, Raffaella, Malendowicz, Ludwik K, Nussdorfer, Gastone G
- Database ID:
- RPEP-00947
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Ghrelin Promotes Adrenal Cell Growth Through MAPK Signaling and Inhibits Apoptosis
What was found?
Ghrelin enhanced adrenal zona glomerulosa cell proliferation through MAPK pathway activation while also inhibiting apoptosis, revealing dual growth-promoting effects on adrenal tissue through functional GHS receptors.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-00947APA
Mazzocchi, Giuseppina; Neri, Giuliano; Rucinski, Marcin; Rebuffat, Piera; Spinazzi, Raffaella; Malendowicz, Ludwik K; Nussdorfer, Gastone G. (2004). Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects.. Peptides, 25(8), 1269-77.
MLA
Mazzocchi, Giuseppina, et al. "Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects.." Peptides, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Ghrelin enhances the growth of cultured human adrenal zona g..." RPEP-00947. Retrieved from https://rethinkpeptides.com/research/mazzocchi-2004-ghrelin-enhances-the-growth
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.