Ghrelin enhanced adrenal zona glomerulosa cell proliferation through MAPK pathway activation while also inhibiting apoptosis, revealing dual growth-promoting effects on adrenal tissue through functional GHS receptors.
Key findingGhrelin stimulated human adrenal zona glomerulosa cell proliferation via p42/p44 MAPK activation and simultaneously inhibited apoptosis through functi
What the researchers found
Ghrelin stimulated human adrenal zona glomerulosa cell proliferation via p42/p44 MAPK activation and simultaneously inhibited apoptosis through functional GHS-R — dual proliferogenic and anti-apoptotic adrenal effects.
Why it matters
Relevant for ghrp, hormone-optimization, cancer, receptor-signaling.
How the study worked
in-vitro study on ghrp, hormone-optimization.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2004.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects.
Peptides, 25(8), 1269-77
Citation
Mazzocchi, Giuseppina; Neri, Giuliano; Rucinski, Marcin; Rebuffat, Piera; Spinazzi, Raffaella; Malendowicz, Ludwik K; Nussdorfer, Gastone G. (2004). Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects.. Peptides, 25(8), 1269-77.