Genetic polymorphisms in the VIP receptor (VPAC1) were associated with rheumatoid arthritis, with RA patients showing altered VIP signaling — genetic evidence for the neuropeptide anti-inflammatory pathway in autoimmunity.
Key findingVPAC1 receptor gene polymorphisms were associated with RA susceptibility, with RA patients showing altered VIP receptor expression and signaling — pro
What the researchers found
VPAC1 receptor gene polymorphisms were associated with RA susceptibility, with RA patients showing altered VIP receptor expression and signaling — providing genetic evidence linking the neuropeptide anti-inflammatory system to autoimmune disease pathogenesis.
Why it matters
Relevant for neuropeptides, inflammation, immune-function.
How the study worked
clinical-trial study.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Genetic association of vasoactive intestinal peptide receptor with rheumatoid arthritis: altered expression and signal in immune cells.
Arthritis and rheumatism, 58(4), 1010-9
Citation
Delgado, Mario; Robledo, Gema; Rueda, Blanca; Varela, Nieves; O'Valle, Francisco; Hernandez-Cortes, Pedro; Caro, Marta; Orozco, Gisela; Gonzalez-Rey, Elena; Martin, Javier. (2008). Genetic association of vasoactive intestinal peptide receptor with rheumatoid arthritis: altered expression and signal in immune cells.. Arthritis and rheumatism, 58(4), 1010-9. https://doi.org/10.1002/art.23482