VIP Receptor Genetic Variants Linked to Rheumatoid Arthritis
Genetic polymorphisms in the VIP receptor (VPAC1) were associated with rheumatoid arthritis, with RA patients showing altered VIP signaling — genetic evidence for the neuropeptide anti-inflammatory pathway in autoimmunity.
Quick Facts
What This Study Found
VPAC1 receptor gene polymorphisms were associated with RA susceptibility, with RA patients showing altered VIP receptor expression and signaling — providing genetic evidence linking the neuropeptide anti-inflammatory system to autoimmune disease pathogenesis.
Key Numbers
How They Did This
clinical-trial study.
Why This Research Matters
Relevant for neuropeptides, inflammation, immune-function.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding VPAC1 receptor gene polymorphisms were associated with RA susceptibility, with RA patients showing altered VIP receptor expression and signaling — pro
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Genetic association of vasoactive intestinal peptide receptor with rheumatoid arthritis: altered expression and signal in immune cells.
- Published In:
- Arthritis and rheumatism, 58(4), 1010-9 (2008)
- Authors:
- Delgado, Mario(10), Robledo, Gema, Rueda, Blanca, Varela, Nieves, O'Valle, Francisco, Hernandez-Cortes, Pedro, Caro, Marta, Orozco, Gisela, Gonzalez-Rey, Elena, Martin, Javier
- Database ID:
- RPEP-01331
Evidence Hierarchy
Frequently Asked Questions
What was studied?
VIP Receptor Genetic Variants Linked to Rheumatoid Arthritis
What was found?
Genetic polymorphisms in the VIP receptor (VPAC1) were associated with rheumatoid arthritis, with RA patients showing altered VIP signaling — genetic evidence for the neuropeptide anti-inflammatory pathway in autoimmunity.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01331APA
Delgado, Mario; Robledo, Gema; Rueda, Blanca; Varela, Nieves; O'Valle, Francisco; Hernandez-Cortes, Pedro; Caro, Marta; Orozco, Gisela; Gonzalez-Rey, Elena; Martin, Javier. (2008). Genetic association of vasoactive intestinal peptide receptor with rheumatoid arthritis: altered expression and signal in immune cells.. Arthritis and rheumatism, 58(4), 1010-9. https://doi.org/10.1002/art.23482
MLA
Delgado, Mario, et al. "Genetic association of vasoactive intestinal peptide receptor with rheumatoid arthritis: altered expression and signal in immune cells.." Arthritis and rheumatism, 2008. https://doi.org/10.1002/art.23482
RethinkPeptides
RethinkPeptides Research Database. "Genetic association of vasoactive intestinal peptide recepto..." RPEP-01331. Retrieved from https://rethinkpeptides.com/research/delgado-2008-genetic-association-of-vasoactive
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.