Neuropeptides (VIP, PACAP, alpha-MSH/KPV, CGRP, cortistatin) form an endogenous class of anti-inflammatory immunoregulatory agents, generating Tregs, suppressing Th1/Th17, and resolving inflammation through specific receptors.
Key findingAnti-inflammatory neuropeptides (VIP, PACAP, alpha-MSH/KPV, CGRP, cortistatin) constitute an endogenous immunoregulatory system: generating regulatory
What the researchers found
Anti-inflammatory neuropeptides (VIP, PACAP, alpha-MSH/KPV, CGRP, cortistatin) constitute an endogenous immunoregulatory system: generating regulatory T-cells, suppressing pathogenic Th1/Th17 responses, and promoting inflammation resolution — nature's own anti-inflammatory drug class.
Why it matters
Relevant for neuropeptides, inflammation, immune-function.
How the study worked
review study.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Anti-inflammatory neuropeptides: a new class of endogenous immunoregulatory agents.
Brain, behavior, and immunity, 22(8), 1146-51
Citation
Delgado, Mario; Ganea, Doina. (2008). Anti-inflammatory neuropeptides: a new class of endogenous immunoregulatory agents.. Brain, behavior, and immunity, 22(8), 1146-51. https://doi.org/10.1016/j.bbi.2008.06.001