GHRH (growth hormone-releasing hormone) unexpectedly activated the GHS-R1a (ghrelin receptor), revealing cross-talk between the two GH-releasing receptor systems that were thought to be completely independent.
Key findingGHRH demonstrated agonist activity at the GHS-R1a (ghrelin receptor) at physiologically relevant concentrations, revealing previously unknown cross-ta
What the researchers found
GHRH demonstrated agonist activity at the GHS-R1a (ghrelin receptor) at physiologically relevant concentrations, revealing previously unknown cross-talk between the GHRH and ghrelin receptor systems — explaining some synergistic GH-releasing effects.
Why it matters
Relevant for ghrp, cjc-1295, receptor-signaling.
How the study worked
in-vitro study.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Growth hormone-releasing hormone as an agonist of the ghrelin receptor GHS-R1a.
Proceedings of the National Academy of Sciences of the United States of America, 105(51), 20452-7
Citation
Casanueva, Felipe F; Camiña, Jesus P; Carreira, Marcos C; Pazos, Yolanda; Varga, Jozsef L; Schally, Andrew V. (2008). Growth hormone-releasing hormone as an agonist of the ghrelin receptor GHS-R1a.. Proceedings of the National Academy of Sciences of the United States of America, 105(51), 20452-7. https://doi.org/10.1073/pnas.0811680106