Surprising: GHRH Can Also Activate the Ghrelin Receptor
GHRH (growth hormone-releasing hormone) unexpectedly activated the GHS-R1a (ghrelin receptor), revealing cross-talk between the two GH-releasing receptor systems that were thought to be completely independent.
Quick Facts
What This Study Found
GHRH demonstrated agonist activity at the GHS-R1a (ghrelin receptor) at physiologically relevant concentrations, revealing previously unknown cross-talk between the GHRH and ghrelin receptor systems — explaining some synergistic GH-releasing effects.
Key Numbers
How They Did This
in-vitro study.
Why This Research Matters
Relevant for ghrp, cjc-1295, receptor-signaling.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding GHRH demonstrated agonist activity at the GHS-R1a (ghrelin receptor) at physiologically relevant concentrations, revealing previously unknown cross-ta
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Growth hormone-releasing hormone as an agonist of the ghrelin receptor GHS-R1a.
- Published In:
- Proceedings of the National Academy of Sciences of the United States of America, 105(51), 20452-7 (2008)
- Authors:
- Casanueva, Felipe F(4), Camiña, Jesus P(2), Carreira, Marcos C(2), Pazos, Yolanda, Varga, Jozsef L, Schally, Andrew V
- Database ID:
- RPEP-01318
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Surprising: GHRH Can Also Activate the Ghrelin Receptor
What was found?
GHRH (growth hormone-releasing hormone) unexpectedly activated the GHS-R1a (ghrelin receptor), revealing cross-talk between the two GH-releasing receptor systems that were thought to be completely independent.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01318APA
Casanueva, Felipe F; Camiña, Jesus P; Carreira, Marcos C; Pazos, Yolanda; Varga, Jozsef L; Schally, Andrew V. (2008). Growth hormone-releasing hormone as an agonist of the ghrelin receptor GHS-R1a.. Proceedings of the National Academy of Sciences of the United States of America, 105(51), 20452-7. https://doi.org/10.1073/pnas.0811680106
MLA
Casanueva, Felipe F, et al. "Growth hormone-releasing hormone as an agonist of the ghrelin receptor GHS-R1a.." Proceedings of the National Academy of Sciences of the United States of America, 2008. https://doi.org/10.1073/pnas.0811680106
RethinkPeptides
RethinkPeptides Research Database. "Growth hormone-releasing hormone as an agonist of the ghreli..." RPEP-01318. Retrieved from https://rethinkpeptides.com/research/casanueva-2008-growth-hormonereleasing-hormone-as
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.