Gut-brain communication for satiety involves two phases: satiation (stopping eating) through vagal mechanoreception and CCK, and satisfaction (staying full) through GLP-1, PYY, and hormonal signaling — a two-phase fullness system.
Key findingPost-meal fullness involves two phases: satiation (meal termination via vagal mechanoreception + CCK) and sustained satisfaction (inter-meal fullness
What the researchers found
Post-meal fullness involves two phases: satiation (meal termination via vagal mechanoreception + CCK) and sustained satisfaction (inter-meal fullness via GLP-1, PYY, insulin, leptin) — distinguishing the immediate fullness signal from prolonged appetite suppression for targeted drug development.
Why it matters
Relevant for neuropeptides, glp-1, weight-loss.
How the study worked
review study.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Vagal and hormonal gut-brain communication: from satiation to satisfaction.
Neurogastroenterology and motility, 20 Suppl 1(0 1), 64-72
Citation
Berthoud, H-R. (2008). Vagal and hormonal gut-brain communication: from satiation to satisfaction.. Neurogastroenterology and motility, 20 Suppl 1(0 1), 64-72. https://doi.org/10.1111/j.1365-2982.2008.01104.x